-transparent.png){kind=logo}
A total of 14 different N-acetylmuramyl-peptides or -amino acids with or without configurations inherent to bacterial cell wall peptidoglycans were synthesized and their pyrogenicities on intravenous injection into rabbits were tested. N-Acetylmuramyl-peptides, and especially N-acetylmuramyl-L-alanyl-D-isoglutamine and N-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-lysine, which were previously shown to be adjuvant-active in both induction of delayed-type hypersensitivity and stimulation of increased serum antibody levels to ovalbumin in guinea pigs, exhibited distinct pyrogenicity at as low dose as 16 mug per rabbit. However, none of the adjuvant-inactive analogues or diastereomers of the above N-acetylmuramyl-dipeptide or related compounds caused any significant febrile response in rabbits, even at a dose of 250 mug per animal.
S Kotani, and
Y Watanabe, and
T Shimono, and
K Harada, and
T Shiba
October 1978,
Zeitschrift fur Immunitatsforschung. Immunobiology,
S Kotani, and
Y Watanabe, and
T Shimono, and
K Harada, and
T Shiba
January 1977,
Infection and immunity,
S Kotani, and
Y Watanabe, and
T Shimono, and
K Harada, and
T Shiba
January 1961,
Bulletin de la Societe de chimie biologique,
S Kotani, and
Y Watanabe, and
T Shimono, and
K Harada, and
T Shiba
January 1979,
Microbiology and immunology,
S Kotani, and
Y Watanabe, and
T Shimono, and
K Harada, and
T Shiba
May 1977,
Proceedings of the National Academy of Sciences of the United States of America,
S Kotani, and
Y Watanabe, and
T Shimono, and
K Harada, and
T Shiba
March 1990,
Proceedings of the National Academy of Sciences of the United States of America,
S Kotani, and
Y Watanabe, and
T Shimono, and
K Harada, and
T Shiba
June 2007,
Vaccine,
S Kotani, and
Y Watanabe, and
T Shimono, and
K Harada, and
T Shiba
February 1968,
Journal of chromatography,
S Kotani, and
Y Watanabe, and
T Shimono, and
K Harada, and
T Shiba
May 1979,
Infection and immunity,
S Kotani, and
Y Watanabe, and
T Shimono, and
K Harada, and
T Shiba
October 1978,
Experientia,
