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BACKGROUND Constant-dose allergen inhalation challenges are frequently used to examine the effect of antiasthma drugs on the allergen-induced early and late asthmatic responses. The end-point measurements in such studies are the maximal early and late percent decreases in the forced expiratory volume in 1 second (FEV1). OBJECTIVE Our purpose was to observe the reproducibility and to determine the sample sizes required for such studies. METHODS Twenty-eight subjects with allergen-induced early and late responses were studied with two constant-dose allergen challenges separated by 2 to 12 weeks. The early response was measured as the maximum percent decrease in FEV1 during the first 2 hours and the late response as the maximum percent decrease in FEV1 between 3 to 7 hours. RESULTS The mean +/- SEM early responses were 23.1% +/- 1.0% and 24.7% +/- 2.0%, whereas the mean late responses were 23.3% +/- 2.0% and 24.5% +/- 2.2%. Reproducibility of measurements were such that fewer than eight subjects are required, to show 50% attenuation of either the early or late response (with 90% power). CONCLUSIONS The method of constant-dose allergen challenge is a sensitive tool for detecting changes in early and late asthmatic responses after the use of antiasthma medication.
M D Inman, and
R Watson, and
D W Cockcroft, and
B J Wong, and
F E Hargreave, and
P M O'Byrne
May 2000,
Respiratory medicine,
M D Inman, and
R Watson, and
D W Cockcroft, and
B J Wong, and
F E Hargreave, and
P M O'Byrne
October 1974,
The Journal of allergy and clinical immunology,
M D Inman, and
R Watson, and
D W Cockcroft, and
B J Wong, and
F E Hargreave, and
P M O'Byrne
September 1993,
The European respiratory journal,
M D Inman, and
R Watson, and
D W Cockcroft, and
B J Wong, and
F E Hargreave, and
P M O'Byrne
November 2015,
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
M D Inman, and
R Watson, and
D W Cockcroft, and
B J Wong, and
F E Hargreave, and
P M O'Byrne
January 1992,
Allergy proceedings : the official journal of regional and state allergy societies,
M D Inman, and
R Watson, and
D W Cockcroft, and
B J Wong, and
F E Hargreave, and
P M O'Byrne
April 1999,
American journal of respiratory and critical care medicine,
M D Inman, and
R Watson, and
D W Cockcroft, and
B J Wong, and
F E Hargreave, and
P M O'Byrne
August 1994,
Thorax,
M D Inman, and
R Watson, and
D W Cockcroft, and
B J Wong, and
F E Hargreave, and
P M O'Byrne
July 1986,
Arerugi = [Allergy],
M D Inman, and
R Watson, and
D W Cockcroft, and
B J Wong, and
F E Hargreave, and
P M O'Byrne
July 1998,
American journal of respiratory and critical care medicine,
M D Inman, and
R Watson, and
D W Cockcroft, and
B J Wong, and
F E Hargreave, and
P M O'Byrne
May 2021,
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology,
