-transparent.png){kind=logo}
We studied 14 kindred and nine unrelated patients from southeastern Brazil with the typical form of hereditary spherocytosis. Diagnosis was made on the basis of clinical features, presence of spherocytes on the peripheral blood smears and an abnormal osmotic fragility test. By densitometric tracing of SDS-PAGE stained by Coomassie blue, we detected isolated deficiency of spectrin in 39% of our patients, combined spectrin and ankyrin deficiency in 13%, and deficiency of band 3 in 13%. One of our patients presented ankyrin deficiency without spectrin reduction. Our data suggest that, despite ethnic differences among the Brazilian and European or North-American populations, these biochemical abnormalities in HS patients may be similar.
S T Saad, and
F F Costa, and
D L Vicentim, and
T S Salles, and
P H Pranke
September 1972,
British journal of haematology,
S T Saad, and
F F Costa, and
D L Vicentim, and
T S Salles, and
P H Pranke
May 1978,
Nihon rinsho. Japanese journal of clinical medicine,
S T Saad, and
F F Costa, and
D L Vicentim, and
T S Salles, and
P H Pranke
January 2003,
Blood cells, molecules & diseases,
S T Saad, and
F F Costa, and
D L Vicentim, and
T S Salles, and
P H Pranke
December 1971,
Biorheology,
S T Saad, and
F F Costa, and
D L Vicentim, and
T S Salles, and
P H Pranke
June 1983,
British journal of haematology,
S T Saad, and
F F Costa, and
D L Vicentim, and
T S Salles, and
P H Pranke
September 1971,
The Journal of clinical investigation,
S T Saad, and
F F Costa, and
D L Vicentim, and
T S Salles, and
P H Pranke
July 2013,
Blood reviews,
S T Saad, and
F F Costa, and
D L Vicentim, and
T S Salles, and
P H Pranke
April 1965,
Seminars in hematology,
S T Saad, and
F F Costa, and
D L Vicentim, and
T S Salles, and
P H Pranke
June 1992,
British journal of haematology,
S T Saad, and
F F Costa, and
D L Vicentim, and
T S Salles, and
P H Pranke
January 1975,
The South African journal of medical sciences,
