Biomaterial Database

Flow-injection determination of Novalgin using amperometric detection at a glassy carbon electrode. 1994

T Pérez-Ruiz, and C Martínez Lozano, and V Tomás

Department of Analytical Chemistry, University of Murcia, Spain.

An electroanalytical study of the oxidation of Novalgin (dipyrone) at a glassy carbon electrode in aqueous solution has been carried out. A flow-injection method with amperometric detection based on this oxidation process is also described. The influence of flow rate, coil length and injection volume on the sensitivity of the method was established. The calibration graph was linear within the range 3 x 10(-6)-3 x 10(-5) M in an ammonia buffer solution (pH 9) as a potential of 0.4 V versus an Ag/AgCl reference electrode. The sampling rate was 54 samples h-1. The applicability of the method to the determination of Novalgin in pharmaceutical preparations was demonstrated by investigating the effect of potential sources of interference and by analysing commercial preparations.

UI	MeSH Term	Description	Entries
D010084	Oxidation-Reduction	A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).	Redox,Oxidation Reduction
D002244	Carbon	A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.	Carbon-12,Vitreous Carbon,Carbon 12,Carbon, Vitreous
D004177	Dipyrone	A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.	Metamizole,Methampyrone,Noramidopyrine Methanesulfonate,Algopyrin,Analgin,Biopyrin,Dipyronium,Metamizol,Metamizole Sodium,Methamizole,Narone,Noramidopyrine Methanesulfonate Sodium,Normelubrine,Novalgetol,Novalgin,Novamidazophen,Novaminsulfone,Optalgin,Pyralgin,Sulpyrin,Sulpyrine
D004364	Pharmaceutical Preparations	Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.	Drug,Drugs,Pharmaceutical,Pharmaceutical Preparation,Pharmaceutical Product,Pharmaceutic Preparations,Pharmaceutical Products,Pharmaceuticals,Preparations, Pharmaceutical,Preparation, Pharmaceutical,Preparations, Pharmaceutic,Product, Pharmaceutical,Products, Pharmaceutical
D004566	Electrodes	Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.	Anode,Anode Materials,Cathode,Cathode Materials,Anode Material,Anodes,Cathode Material,Cathodes,Electrode,Material, Anode,Material, Cathode
D015374	Biosensing Techniques	Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.	Bioprobes,Biosensors,Electrodes, Enzyme,Biosensing Technics,Bioprobe,Biosensing Technic,Biosensing Technique,Biosensor,Electrode, Enzyme,Enzyme Electrode,Enzyme Electrodes,Technic, Biosensing,Technics, Biosensing,Technique, Biosensing,Techniques, Biosensing
D017022	Flow Injection Analysis	The analysis of a chemical substance by inserting a sample into a carrier stream of reagent using a sample injection valve that propels the sample downstream where mixing occurs in a coiled tube, then passes into a flow-through detector and a recorder or other data handling device.	Analysis, Flow Injection,Analyses, Flow Injection,Flow Injection Analyses,Injection Analyses, Flow,Injection Analysis, Flow