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Intranasal administration of gonadotropin hormone (GnRH) in doses ranging from 2-4 mg produced a consistently prolonged LH response in patients with secondary amenorrhea. In 4 cases, a delayed secondary rise occurred. A similarly prolonged FSH response was observed in the majority of patients. Six hours after intranasal GnRH, FSH and LH values were well above basal levels and were higher than those observed at a similar interval after intravenous GnRH. Plasma GnRH levels after intranasal administration failed to achieve the high peaks found after the intravenous route but maintained elevated levels for at least an hour and often longer. Despite the much lower plasma GnRH levels, intranasal GnRH produced a sustained effect on LH and FSH secretion, greater than GnRH given by the intravenous route.
M Katz, and
B L Pimstone, and
P J Carr, and
S Hendricks
November 1974,
The Journal of endocrinology,
M Katz, and
B L Pimstone, and
P J Carr, and
S Hendricks
October 1984,
Acta endocrinologica,
M Katz, and
B L Pimstone, and
P J Carr, and
S Hendricks
March 1995,
European journal of pediatrics,
M Katz, and
B L Pimstone, and
P J Carr, and
S Hendricks
March 1990,
Biology of reproduction,
M Katz, and
B L Pimstone, and
P J Carr, and
S Hendricks
July 1982,
Lancet (London, England),
M Katz, and
B L Pimstone, and
P J Carr, and
S Hendricks
January 1983,
Archives of gynecology,
M Katz, and
B L Pimstone, and
P J Carr, and
S Hendricks
January 1974,
Fortschritte der Andrologie,
M Katz, and
B L Pimstone, and
P J Carr, and
S Hendricks
June 1981,
Ugeskrift for laeger,
M Katz, and
B L Pimstone, and
P J Carr, and
S Hendricks
November 1985,
The Journal of clinical endocrinology and metabolism,
M Katz, and
B L Pimstone, and
P J Carr, and
S Hendricks
August 1979,
Lancet (London, England),
