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The pattern of LHRH-evoked release of LH and FSH by pituitary gonadotrophs and the concomitant gonadal steroid secretion were studied in 28 pubertal and 16 prepubertal children. LHRH was administered at doses of 100 mug and 10 mug by a constant-infusion pump over 3 hours following a 2-hour control period. Gonadotropin concentrations were measured at 15-minutes intervals. Mean LH concentrations rose from 2.0 +/- 0.4 (SE) mIU/ml (IRP-2-hMG) to 6.2 +/- 0.9 (P less than .001) in normal prepubertal and from 5.8 +/- 0.9 to 28.0 +/- 3.6 (P less than .001) in normal pubertal children. The peak rise of LH, the mean level attained during the LHRH infusion, and the area under the time-response curve were greater (P less than .001) in pubertal than prepubertal children. The serum LH rise had two components in pubertal children in contrast to a single-phased increase in prepubertal children. Pulsatile release of LH was demonstrated during the basal period in pubertal children and during the LHRH infusion in both groups. FSH release was greater in girls than boys at both stages of pubertal development. A 10 mug LHRH infusion released less LH than did 100 mug in the pubertal children, but more than in prepubertal children. In pubertal boys, plasma testosterone rose (P less than .001) from 222 +/- 45 ng/dl in the control period to 301 +/- 59 following 100 mug LHRH. There was no change in plasma testosterone in the prepubertal boys after 100 mug LHRH or in the pubertal boys following 10 mug LHRH. Plasma estradiol did not rise in girls of either maturity group. In children with hypogonadotropic hypogonadism and structural abnormalities of the hypothalamic-pituitary region, there was no LHRH-evoked gonadotropin release. In 2 agonadal girls, the secretion of LH and FSH was greatly exaggerated. The 3-hour LHRH infusion evoked a maturity-related pituitary LH release and a sex-specific FSH release; a 2-phased pattern of LH secretion was present in pubertal but not in prepubertal children; pulsatile LH release was evoked by the LHRH infusion in prepubertal children.
E O Reiter, and
A W Root, and
G E Duckett
January 1974,
Neuroendocrinology,
E O Reiter, and
A W Root, and
G E Duckett
February 1978,
Endokrinologie,
E O Reiter, and
A W Root, and
G E Duckett
March 1983,
Endocrinology,
E O Reiter, and
A W Root, and
G E Duckett
July 1986,
Journal of dairy science,
E O Reiter, and
A W Root, and
G E Duckett
July 1982,
Acta paediatrica Scandinavica,
E O Reiter, and
A W Root, and
G E Duckett
October 1998,
Nihon Ika Daigaku zasshi,
E O Reiter, and
A W Root, and
G E Duckett
September 2000,
European journal of endocrinology,
E O Reiter, and
A W Root, and
G E Duckett
August 1981,
Psychological medicine,
E O Reiter, and
A W Root, and
G E Duckett
June 1984,
Biology of reproduction,
E O Reiter, and
A W Root, and
G E Duckett
August 1990,
Biology of reproduction,
