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This study was performed to evaluate whether the presence or absence of somatostatin receptors in malignant carcinoid tumours detected by [111In-DTPA-D-Phe1]octreotide scintigraphy can be used to predict response to somatostatin analogue treatment. Thirty patients were investigated, 28 with midgut carcinoid tumours and two with foregut carcinoid tumours. Twenty-seven patients showed pathological uptake in tumour lesions at scintigraphy; of these, 22 responded to somatostatin analogue treatment using octreotide, somatuline or octastatin, while five patients failed to respond. None of the three patients displaying negative scintigraphic investigations responded to treatment with somatostatin analogues. These results show a good correlation between the somatostatin receptor status and the patients' ability to respond to somatostatin analogue treatment (p = 0.014). We conclude that somatostatin receptor scintigraphy using [111In-DTPA-D-Phe1]octreotide can be used to select patients with malignant carcinoid tumours suitable for somatostatin analogue treatment and exclude those that will not benefit from such medication.
E T Janson, and
J E Westlin, and
B Eriksson, and
H Ahlström, and
S Nilsson, and
K Oberg
March 1998,
Clinical endocrinology,
E T Janson, and
J E Westlin, and
B Eriksson, and
H Ahlström, and
S Nilsson, and
K Oberg
February 1994,
The Quarterly journal of medicine,
E T Janson, and
J E Westlin, and
B Eriksson, and
H Ahlström, and
S Nilsson, and
K Oberg
April 1994,
European journal of nuclear medicine,
E T Janson, and
J E Westlin, and
B Eriksson, and
H Ahlström, and
S Nilsson, and
K Oberg
January 1993,
Acta oncologica (Stockholm, Sweden),
E T Janson, and
J E Westlin, and
B Eriksson, and
H Ahlström, and
S Nilsson, and
K Oberg
September 1994,
Annals of the New York Academy of Sciences,
E T Janson, and
J E Westlin, and
B Eriksson, and
H Ahlström, and
S Nilsson, and
K Oberg
January 2002,
European journal of drug metabolism and pharmacokinetics,
E T Janson, and
J E Westlin, and
B Eriksson, and
H Ahlström, and
S Nilsson, and
K Oberg
August 1993,
European journal of nuclear medicine,
E T Janson, and
J E Westlin, and
B Eriksson, and
H Ahlström, and
S Nilsson, and
K Oberg
June 2000,
European journal of nuclear medicine,
E T Janson, and
J E Westlin, and
B Eriksson, and
H Ahlström, and
S Nilsson, and
K Oberg
October 2000,
European journal of nuclear medicine,
E T Janson, and
J E Westlin, and
B Eriksson, and
H Ahlström, and
S Nilsson, and
K Oberg
April 2000,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
