-transparent.png){kind=logo}
We have advanced the hypothesis that polyamines affect DNA methylation and thus promote the expression of developmentally controlled genes. We demonstrate that the activity of cytosine-DNA methyltransferases HpaII, HhaI, HaeIII and SssI is inhibited by physiological concentrations of polyamines. On the other hand, activity of the adenine-DNA methyltransferase EcoRI, and restriction enzymes HpaII, HhaI, HaeIII and EcoRI, is insensitive to polyamine concentrations up to 40 mM. Our results indicate that the effect of polyamines on cytosine-DNA methyltransferases is rather selective and suggest a possible mode of action in vivo.
Related Publications
J Ruiz-Herrera, and
R Ruiz-Medrano, and
A Domínguez
October 1994,
The Journal of biological chemistry,
J Ruiz-Herrera, and
R Ruiz-Medrano, and
A Domínguez
March 1981,
Molecular pharmacology,
J Ruiz-Herrera, and
R Ruiz-Medrano, and
A Domínguez
December 1989,
Nucleic acids research,
J Ruiz-Herrera, and
R Ruiz-Medrano, and
A Domínguez
January 2024,
Applied microbiology and biotechnology,
J Ruiz-Herrera, and
R Ruiz-Medrano, and
A Domínguez
February 1978,
Nucleic acids research,
J Ruiz-Herrera, and
R Ruiz-Medrano, and
A Domínguez
June 1978,
Doklady Akademii nauk SSSR,
J Ruiz-Herrera, and
R Ruiz-Medrano, and
A Domínguez
January 1976,
Doklady Akademii nauk SSSR,
J Ruiz-Herrera, and
R Ruiz-Medrano, and
A Domínguez
December 1984,
Biochemistry international,
J Ruiz-Herrera, and
R Ruiz-Medrano, and
A Domínguez
March 1972,
Biochemical and biophysical research communications,
J Ruiz-Herrera, and
R Ruiz-Medrano, and
A Domínguez
September 1979,
Nucleic acids research,
