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The ammonia concentration and changes in the activity of ammonia metabolizing enzymes in the brain tissue during ischemia/reperfusion were investigated in rats. During ischemia (0.5 h) we found a statistically significant increase in brain ammonia concentration and a significant decrease in glutamate dehydrogenase activity. After 1 h of reperfusion, a further accumulation of ammonia concentration was observed. Furthermore, the brain glutamine syntethase and glutamate dehydrogenase were decreased, whereas the brain glutaminase activity was increased. The causes for the changed activities of some ammonia metabolizing enzymes in brain after ischemia/reperfusion have been discussed.
A Hołownia, and
M Chwiecko, and
R Farbiszewski
September 1989,
Biochemical pharmacology,
A Hołownia, and
M Chwiecko, and
R Farbiszewski
December 1988,
Biochemical medicine and metabolic biology,
A Hołownia, and
M Chwiecko, and
R Farbiszewski
January 1991,
Drug and alcohol dependence,
A Hołownia, and
M Chwiecko, and
R Farbiszewski
September 2004,
General physiology and biophysics,
A Hołownia, and
M Chwiecko, and
R Farbiszewski
July 2006,
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology,
A Hołownia, and
M Chwiecko, and
R Farbiszewski
December 2007,
Neurological research,
A Hołownia, and
M Chwiecko, and
R Farbiszewski
January 1987,
Folia medica,
A Hołownia, and
M Chwiecko, and
R Farbiszewski
October 2019,
Physiological measurement,
A Hołownia, and
M Chwiecko, and
R Farbiszewski
August 1993,
Molecular and cellular biochemistry,
A Hołownia, and
M Chwiecko, and
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June 1999,
Circulation research,
