Biomaterial Database

[Maternal age as a risk factor for congenital malformations]. 1994

J Nazer, and L Cifuentes, and G Ruiz, and M T Pizarro

Departamento de Biología Celular y Genética, Facultad de Medicina, Universidad de Chile, Hospital José Joaquín Aguirre, Santiago de Chile.

We studied 131,899 consecutive births at the Maternity of the University of Chile Clinical Hospital, finding 4887 newborns with congenital malformations (representing a rate of 37.05 per 1000 alive newborns). Between January 1982 and December 1992 there were 41,344 births and 295 stillbirths (0.7%). Among the latter, 41 were malformed (13.9%). A graphic comparing the mean annual rates of malformations and maternal ages, shows a sustained increase in malformations form 1972 to 1988, that decreases thereafter and stabilizes since 1982. There is a marked parallelism between the curves of malformation rates and maternal age (t21 = 1.057, p < 0.1). It is concluded that the risk of congenital malformations increases along with maternal ages.

UI	MeSH Term	Description	Entries
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008423	Maternal Age	The age of the mother in PREGNANCY.	Age, Maternal,Ages, Maternal,Maternal Ages
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D002677	Chile	A country in southern South America, bordering the South Pacific Ocean, between Argentina and Peru.
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000013	Congenital Abnormalities	Malformations of organs or body parts during development in utero.	Birth Defects,Congenital Defects,Deformities,Fetal Anomalies,Fetal Malformations,Abnormalities, Congenital,Defects, Congenital,Abnormality, Congenital,Anomaly, Fetal,Birth Defect,Congenital Abnormality,Congenital Defect,Defect, Birth,Defect, Congenital,Deformity,Fetal Anomaly,Fetal Malformation,Malformation, Fetal
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D012307	Risk Factors	An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent.	Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D015994	Incidence	The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases in the population at a given time.	Attack Rate,Cumulative Incidence,Incidence Proportion,Incidence Rate,Person-time Rate,Secondary Attack Rate,Attack Rate, Secondary,Attack Rates,Cumulative Incidences,Incidence Proportions,Incidence Rates,Incidence, Cumulative,Incidences,Person time Rate,Person-time Rates,Proportion, Incidence,Rate, Attack,Rate, Incidence,Rate, Person-time,Rate, Secondary Attack,Secondary Attack Rates