-transparent.png){kind=logo}
A high incidence of spontaneous amyloidosis is described in SJL/J mice. Amyloid was detected as early as 30 weeks of age and the incidence rose to 90 per cent by 60 weeks of age. Amyloid deposits were most prominent in the perifollicular zones of the spleen and the lobular areas of the liver. Ultrastructural analysis revealed rigid, nonbranching fibrils indistinguishable from those observed in casein-induced murine amyloidosis. On the other hand, immunochemical studies indicated that amyloid deposits in SJL/J mice differ from those found in casein-treated CBA mice with respect to size, amino acid content, and antigenic properties. Since the SJL/J mouse also develops spontaneous reticulum cell tumors and serum M components, it appears to be a useful model for study of the pathogenesis of amyloidosis and its relationship to aging, neoplasia, and certain B-cell dyscrasias.
M A Scheinberg, and
E S Cathcart, and
J W Eastcott, and
M Skinner, and
M Benson, and
T Shirahama
May 2002,
Hepatology (Baltimore, Md.),
M A Scheinberg, and
E S Cathcart, and
J W Eastcott, and
M Skinner, and
M Benson, and
T Shirahama
January 1997,
Muscle & nerve,
M A Scheinberg, and
E S Cathcart, and
J W Eastcott, and
M Skinner, and
M Benson, and
T Shirahama
September 1982,
Mechanisms of ageing and development,
M A Scheinberg, and
E S Cathcart, and
J W Eastcott, and
M Skinner, and
M Benson, and
T Shirahama
January 1970,
Zeitschrift fur Versuchstierkunde,
M A Scheinberg, and
E S Cathcart, and
J W Eastcott, and
M Skinner, and
M Benson, and
T Shirahama
July 1978,
The American journal of pathology,
M A Scheinberg, and
E S Cathcart, and
J W Eastcott, and
M Skinner, and
M Benson, and
T Shirahama
September 1967,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
M A Scheinberg, and
E S Cathcart, and
J W Eastcott, and
M Skinner, and
M Benson, and
T Shirahama
May 1973,
Journal of the National Cancer Institute,
M A Scheinberg, and
E S Cathcart, and
J W Eastcott, and
M Skinner, and
M Benson, and
T Shirahama
October 1983,
Journal of the National Cancer Institute,
M A Scheinberg, and
E S Cathcart, and
J W Eastcott, and
M Skinner, and
M Benson, and
T Shirahama
January 1987,
ASAIO transactions,
M A Scheinberg, and
E S Cathcart, and
J W Eastcott, and
M Skinner, and
M Benson, and
T Shirahama
September 1981,
Laboratory investigation; a journal of technical methods and pathology,
