A diameter-based reconstruction of the branching pattern of the human bronchial tree. Part I. Description and application. 1994

C G Phillips, and S R Kaye, and R C Schroter
Centre for Biological and Medical Systems, Imperial College of Science, Technology and Medicine, London, UK.

We propose an analysis of the branching pattern of the conducting airways of the human bronchial tree, based on classifying airways by diameter rather than by some essentially topological measure of their position in the whole lung. A diameter-based statistical reconstruction technique is applied to the partial measurements of airway dimensions made by Raabe et al. (1976), to quantify some aspects of bronchial geometry likely to influence transport processes in the lung. We give predictions for the total number of airways with each diameter, and for the partitioning of the total bronchial wall area and airway volume between airways of different diameters. We also consider the variability of the lengths of different pathways through the bronchial tree, and using a simple model for the distribution of air flow in the lung, we predict how the average flow velocity depends on airway diameter. Comparison of these results with equivalent predictions derived from Weibel's symmetrical lung model shows qualitative differences, which probably result from Weibel's use of extrapolation techniques to compensate for the lack of data on smaller conducting airways. Comparison with the predictions of Horsfield and Cumming's asymmetrical lung model shows generally good agreement, although there are significant differences relating to the asymmetry of bifurcations and to the diameter-dependence of the flow velocity in the smallest conducting airways.

UI MeSH Term Description Entries
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008322 Mammals Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young. Mammalia,Mammal
D008953 Models, Anatomic Three-dimensional representation to show anatomic structures. Models may be used in place of intact animals or organisms for teaching, practice, and study. Anatomic Models,Models, Surgical,Moulages,Models, Anatomical,Anatomic Model,Anatomical Model,Anatomical Models,Model, Anatomic,Model, Anatomical,Model, Surgical,Moulage,Surgical Model,Surgical Models
D001980 Bronchi The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI. Primary Bronchi,Primary Bronchus,Secondary Bronchi,Secondary Bronchus,Tertiary Bronchi,Tertiary Bronchus,Bronchi, Primary,Bronchi, Secondary,Bronchi, Tertiary,Bronchus,Bronchus, Primary,Bronchus, Secondary,Bronchus, Tertiary
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000403 Airway Resistance Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow. Airway Resistances,Resistance, Airway,Resistances, Airway
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

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