BIOMAT Database Logo BIOMAT Database Logo

[The conformational aspects of the interaction of the cholinesterases of Pacific Ocean squid and vertebrates with derivatives of polymethylene bis(trimethylammonium)]. 1994

E V Rozengart, and B S Zhorov, and A E Khovanskikh, and N N Shestakova, and L M Epshteĭn

Conformational properties of a series of polymethylenebis (trimethylammonium) derivatives [formula: see text] (n = 4-10), cholinesterase reversible inhibitors, were studied by molecular mechanics method. Conformation-activity relationships between these inhibitors and human erythrocyte acetylcholinesterase, horse plasma butyrylcholinesterase, cholinesterases from the brain of the frog Rana temporaria and from visual ganglia of the squid Todarodes pacificus were investigated by correlational methods. Differences in mechanisms of antienzyme actions were determined.

UI MeSH Term Description Entries
D008725 Bis-Trimethylammonium Compounds Compounds containing polymethylene bis-trimethylammonium cations. Members of this group frequently act as ganglionic blockers and neuromuscular depolarizing agents. Methonium Compounds,Bis-Trimethyl-Ammonium Compounds,Bis Trimethyl Ammonium Compounds,Bis Trimethylammonium Compounds
D011487 Protein Conformation The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain). Conformation, Protein,Conformations, Protein,Protein Conformations
D011896 Rana temporaria A species of the family Ranidae occurring in a wide variety of habitats from within the Arctic Circle to South Africa, Australia, etc. European Common Frog,Frog, Common European,Common European Frog,Common Frog, European,European Frog, Common,Frog, European Common
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D002091 Butyrylcholinesterase An aspect of cholinesterase (EC 3.1.1.8). Pseudocholinesterase,Benzoylcholinesterase,Butyrylthiocholinesterase
D002800 Cholinesterase Inhibitors Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. Acetylcholinesterase Inhibitor,Acetylcholinesterase Inhibitors,Anti-Cholinesterase,Anticholinesterase,Anticholinesterase Agent,Anticholinesterase Agents,Anticholinesterase Drug,Cholinesterase Inhibitor,Anti-Cholinesterases,Anticholinesterase Drugs,Anticholinesterases,Cholinesterase Inhibitors, Irreversible,Cholinesterase Inhibitors, Reversible,Agent, Anticholinesterase,Agents, Anticholinesterase,Anti Cholinesterase,Anti Cholinesterases,Drug, Anticholinesterase,Drugs, Anticholinesterase,Inhibitor, Acetylcholinesterase,Inhibitor, Cholinesterase,Inhibitors, Acetylcholinesterase,Inhibitors, Cholinesterase,Inhibitors, Irreversible Cholinesterase,Inhibitors, Reversible Cholinesterase,Irreversible Cholinesterase Inhibitors,Reversible Cholinesterase Inhibitors
D002802 Cholinesterases Acylcholineacylhydrolase,Cholase,Cholinesterase
D004912 Erythrocytes Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN. Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D006736 Horses Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest. Equus caballus,Equus przewalskii,Horse, Domestic,Domestic Horse,Domestic Horses,Horse,Horses, Domestic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

E V Rozengart, and B S Zhorov, and A E Khovanskikh, and N N Shestakova, and L M Epshteĭn
Conformational aspects of the interaction of various cholinesterases with polymethylene-bis(trimethylammonium) derivatives.
January 2002, Doklady. Biochemistry and biophysics,
E V Rozengart, and B S Zhorov, and A E Khovanskikh, and N N Shestakova, and L M Epshteĭn
[Interaction between various cholinesterases and reversible inhibitors of polymethylene-bis-(trimethylammonium) diiodide series].
January 1983, Ukrainskii biokhimicheskii zhurnal (1978),
E V Rozengart, and B S Zhorov, and A E Khovanskikh, and N N Shestakova, and L M Epshteĭn
[The interaction of hexamethonium derivatives with the cholinesterases of vertebrates and invertebrates. The physicochemical and conformational aspects].
January 1995, Zhurnal evoliutsionnoi biokhimii i fiziologii,
E V Rozengart, and B S Zhorov, and A E Khovanskikh, and N N Shestakova, and L M Epshteĭn
[The conformational-correlational aspects of the substrate specificity of the cholinesterases in the Pacific Ocean squid Todarones pacificus and in mammals].
January 1999, Zhurnal evoliutsionnoi biokhimii i fiziologii,
E V Rozengart, and B S Zhorov, and A E Khovanskikh, and N N Shestakova, and L M Epshteĭn
[Pharmacology of bis (trimethylammonium) polymethylene compounds (methonium salts)].
April 1953, Archivio italiano di scienze farmacologiche,
E V Rozengart, and B S Zhorov, and A E Khovanskikh, and N N Shestakova, and L M Epshteĭn
A comparative study of interaction of reversible onium inhibitors with cholinesterases of the Pacific squid Todarodes pacificus and some other vertebrates.
January 2009, Doklady. Biochemistry and biophysics,
E V Rozengart, and B S Zhorov, and A E Khovanskikh, and N N Shestakova, and L M Epshteĭn
[A comparative study of the interaction of cholinesterases in Pacific Ocean squid (Berryteuthis magister) and some mammals with silatrane-onium inhibitors].
January 1997, Zhurnal evoliutsionnoi biokhimii i fiziologii,
E V Rozengart, and B S Zhorov, and A E Khovanskikh, and N N Shestakova, and L M Epshteĭn
[The specificity of the interaction of the cholinesterases in Far Eastern squid and certain vertebrates with reversible inhibitors].
January 1988, Zhurnal evoliutsionnoi biokhimii i fiziologii,
E V Rozengart, and B S Zhorov, and A E Khovanskikh, and N N Shestakova, and L M Epshteĭn
[The interaction of organosilicon bisammonium compounds with the cholinesterases of Far-Eastern squids and vertebrates. The comparative enzymological, kinetic and conformational aspects].
January 1995, Zhurnal evoliutsionnoi biokhimii i fiziologii,
E V Rozengart, and B S Zhorov, and A E Khovanskikh, and N N Shestakova, and L M Epshteĭn
[Inhibition of cholinesterases by aziridinium derivatives of polymethylene bischloroethylamines].
July 1983, Bioorganicheskaia khimiia,
Copied contents to your clipboard!