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BACKGROUND Secretory component (SC), Clara cell protein (CC10) and to some extent, IgM are proteins locally synthetized in airways. Albumin, alpha 2-macroglobulin and alpha 1-antitrypsin are mainly plasma proteins. In patients with asthma, blood proteins may occur in greater amounts in bronchoalveolar lavage fluid (BALF) than in control subjects because of plasma extravasation. These proteins were measured in BALF to define markers of local synthesis and plasma exudation. METHODS Twenty-four patients with asthma (mean age, 40 +/- 3.1 years) and 24 control subjects (mean age, 29 +/- 11 years) were tested. Five aliquots of saline solution (50 ml) were instilled, and the recovered BALF was stored. Clara cell protein was measured by a sensitive immunoassay technique based on the agglutination of latex particles. SC, immunoglobulins, alpha 2-macroglobulin, alpha 1-antitrypsin, and albumin were measured by an immunoradiometric assay. Protein concentrations were normalized to albumin. RESULTS In BALF from patients with asthma there was a significant increase in alpha 2-macroglobulin and IgM and a significant decrease of SC, alpha 1-antitrypsin, and Clara cell protein compared with control subjects. Also, the ratio to albumin was significantly increased for alpha 2-macroglobulin and IgM and decreased for SC. There was no correlation between the severity of asthma and the amount of proteins. CONCLUSIONS BALF protein content is significantly different in patients with asthma and control subjects, for proteins produced locally and derived from plasma.
T Van Vyve, and
P Chanez, and
A Bernard, and
J Bousquet, and
P Godard, and
R Lauwerijs, and
Y Sibille
November 1995,
American journal of respiratory and critical care medicine,
T Van Vyve, and
P Chanez, and
A Bernard, and
J Bousquet, and
P Godard, and
R Lauwerijs, and
Y Sibille
July 2007,
American journal of respiratory and critical care medicine,
T Van Vyve, and
P Chanez, and
A Bernard, and
J Bousquet, and
P Godard, and
R Lauwerijs, and
Y Sibille
June 1991,
Scandinavian journal of immunology,
T Van Vyve, and
P Chanez, and
A Bernard, and
J Bousquet, and
P Godard, and
R Lauwerijs, and
Y Sibille
December 1991,
Zentralblatt fur Hygiene und Umweltmedizin = International journal of hygiene and environmental medicine,
T Van Vyve, and
P Chanez, and
A Bernard, and
J Bousquet, and
P Godard, and
R Lauwerijs, and
Y Sibille
July 1993,
The American review of respiratory disease,
T Van Vyve, and
P Chanez, and
A Bernard, and
J Bousquet, and
P Godard, and
R Lauwerijs, and
Y Sibille
January 2003,
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego,
T Van Vyve, and
P Chanez, and
A Bernard, and
J Bousquet, and
P Godard, and
R Lauwerijs, and
Y Sibille
August 1996,
The European respiratory journal. Supplement,
T Van Vyve, and
P Chanez, and
A Bernard, and
J Bousquet, and
P Godard, and
R Lauwerijs, and
Y Sibille
June 1984,
Chest,
T Van Vyve, and
P Chanez, and
A Bernard, and
J Bousquet, and
P Godard, and
R Lauwerijs, and
Y Sibille
June 1993,
The American review of respiratory disease,
T Van Vyve, and
P Chanez, and
A Bernard, and
J Bousquet, and
P Godard, and
R Lauwerijs, and
Y Sibille
January 2023,
Journal of veterinary internal medicine,
