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The in vivo effects of alacepril (1-[(S)-3-acetylthio-2-methylpropanoyl]- L-prolyl-L-phenylalanine), an angiotensin converting enzyme inhibitor, and SC-52458 (5-[(3,5-dibutyl-1H-1,2,4-triazol-1- yl)methyl]-2-[2-(1H-tetrazol-5-ylphenyl)]pyridine), an angiotensin AT1 receptor antagonist, were examined on the cardiac and aortic gene expressions of extracellular matrices and TGF-beta 1 in young spontaneously hypertensive rats (SHR). In SHR, types I and III collagen mRNAs were increased in the left ventricle, and in contrast, fibronectin, collagen IV, and transforming growth factor-beta 1 (TGF-beta 1) mRNAs were increased in aorta, compared with those in Wistar-Kyoto rats. All the enhanced mRNAs in both organs in SHR were significantly inhibited by the short-term treatment with the above two drugs. Thus, angiotensin AT1 receptor may play an important role in the regulation of extracellular matrices and TGF-beta 1 expressions in SHR.
K Ohta, and
S Kim, and
A Hamaguchi, and
T Yukimura, and
K Miura, and
K Takaori, and
H Iwao
March 2004,
Chest,
K Ohta, and
S Kim, and
A Hamaguchi, and
T Yukimura, and
K Miura, and
K Takaori, and
H Iwao
January 1990,
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K Ohta, and
S Kim, and
A Hamaguchi, and
T Yukimura, and
K Miura, and
K Takaori, and
H Iwao
June 1994,
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K Ohta, and
S Kim, and
A Hamaguchi, and
T Yukimura, and
K Miura, and
K Takaori, and
H Iwao
June 1993,
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K Ohta, and
S Kim, and
A Hamaguchi, and
T Yukimura, and
K Miura, and
K Takaori, and
H Iwao
December 1990,
Cell differentiation and development : the official journal of the International Society of Developmental Biologists,
K Ohta, and
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A Hamaguchi, and
T Yukimura, and
K Miura, and
K Takaori, and
H Iwao
January 1998,
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K Ohta, and
S Kim, and
A Hamaguchi, and
T Yukimura, and
K Miura, and
K Takaori, and
H Iwao
September 1994,
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K Ohta, and
S Kim, and
A Hamaguchi, and
T Yukimura, and
K Miura, and
K Takaori, and
H Iwao
January 1990,
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K Ohta, and
S Kim, and
A Hamaguchi, and
T Yukimura, and
K Miura, and
K Takaori, and
H Iwao
January 2009,
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K Ohta, and
S Kim, and
A Hamaguchi, and
T Yukimura, and
K Miura, and
K Takaori, and
H Iwao
October 1995,
Kidney international,
