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The antigenicity of deep-frozen and freeze-dried cortical and corticocancellous bone allografts placed orthotopically in rabbits was studied using a sensitive microcytotoxicity assay. Target cells were phytohemagglutinin-P-stimulated, 51chromium-labeled peripheral blood lymphocytes from the bone donors (Dutch belted rabbits), and sera or peripheral blood lymphocytes from the graft recipients (New Zealand white rabbits) were used as effectors of cytotoxicity. Fresh allografts and deep-frozen corticocancellous bone evoked detectable humoral and cell-mediated immunity,, whereas freeze-dried cortical bone allografts failed to sensitize the recipients and were the least antigenic of the allografts examined.
G E Friedlaender, and
D M Strong, and
K W Sell
October 2007,
Cryobiology,
G E Friedlaender, and
D M Strong, and
K W Sell
January 1970,
Cryobiology,
G E Friedlaender, and
D M Strong, and
K W Sell
September 1987,
Archives of otolaryngology--head & neck surgery,
G E Friedlaender, and
D M Strong, and
K W Sell
October 1989,
The Laryngoscope,
G E Friedlaender, and
D M Strong, and
K W Sell
January 1985,
General dentistry,
G E Friedlaender, and
D M Strong, and
K W Sell
January 1984,
Shiyo. The journal of the Tokyo Dental Association,
G E Friedlaender, and
D M Strong, and
K W Sell
July 1991,
Dental clinics of North America,
G E Friedlaender, and
D M Strong, and
K W Sell
January 1983,
Journal of periodontology,
G E Friedlaender, and
D M Strong, and
K W Sell
January 1981,
Journal of periodontal research,
G E Friedlaender, and
D M Strong, and
K W Sell
October 2009,
Journal of biomechanics,
