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Stereoselective disposition of ibuprofen enantiomers in infants. 1994
E Rey, and
A Pariente-Khayat, and
L Gouyet, and
F Vauzelle-Kervroëdan, and
G Pons, and
P D'Athis, and
M C Dubois, and
I Murat, and
C Lassale, and
M Goehrs
Département de Pharmacologie Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Paris, France.
The pharmacokinetics of the enantiomers of ibuprofen were investigated after oral administration of a single 7.6 +/- 0.3 mg kg-1 dose of the racemate in 11 infants. Mean (+/- s.d.) half-lives were 1.6 +/- 0.5 h for S(+) and 1.5 +/- 0.5 h for R(-) and mean (+/- s.d.) AUC values were 31.5 +/- 14.3 mg l-1 h for S(+) and 36.6 +/- 13.8 mg l-1 h for R(-). Since plasma concentrations of the active S(+)-isomer were lower than those reported in adults, a higher dosage might be required in infants.
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