-transparent.png){kind=logo}
1. Chronic alcohol feeding with a low-fat diet (4.4% total calories) produced a two- to three-fold increase in hepatic triacylglycerol and esterified cholesterol compared with pair-fed low-fat diet controls. Plasma lipids were similar in both groups. 2. Hepatic fatty acid synthesis rates measured in vivo with 3H2O were significantly lower in the alcohol-fed animals than in controls. Activities of hepatic fatty acid synthase (EC 2.3.1.85) and acetyl-CoA carboxylase (EC 6.4.1.2) were reduced in the alcohol-fed rats. 3. These results indicate that enhanced hepatic fatty acid synthesis does not occur in rats fed alcohol and a low-fat diet for 4 weeks, and is thus not implicated in the pathogenesis of alcohol-induced fatty liver.
K J Simpson, and
S Venkatesan, and
T J Peters
August 1987,
Clinical science (London, England : 1979),
K J Simpson, and
S Venkatesan, and
T J Peters
May 1996,
The Journal of clinical investigation,
K J Simpson, and
S Venkatesan, and
T J Peters
August 1984,
Acta pharmacologica et toxicologica,
K J Simpson, and
S Venkatesan, and
T J Peters
June 2015,
Lipids,
K J Simpson, and
S Venkatesan, and
T J Peters
January 1987,
Digestive diseases and sciences,
K J Simpson, and
S Venkatesan, and
T J Peters
September 1996,
The American journal of physiology,
K J Simpson, and
S Venkatesan, and
T J Peters
April 1988,
The Biochemical journal,
K J Simpson, and
S Venkatesan, and
T J Peters
January 1975,
Polish medical sciences and history bulletin,
K J Simpson, and
S Venkatesan, and
T J Peters
January 2019,
World journal of gastroenterology,
K J Simpson, and
S Venkatesan, and
T J Peters
November 2023,
Nutrients,
