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Although gamma delta T cells have been postulated to act as a surveillance mechanism that eliminates transformed or otherwise damaged cells, little is known about tumor recognition by gamma delta T cells, including the Ags that are recognized and the molecules that present them. Previously, we described human gamma delta CTL that recognize the autologous B cell lymphoma. Here we report that these gamma delta CTL lyse heterologous cells transfected with the tumor Ig lambda chain gene. Furthermore, the lambda chain is recognized as processed peptide in an Id-specific manner. T cell recognition does not involve classical MHC molecules, but it could be blocked by Abs directed against the heat shock protein grp75. These findings show a specific gamma delta T cell response to a highly polymorphic Ag such as tumor Id and implicate heat shock protein as a molecule required for recognition.
H T Kim, and
E L Nelson, and
C Clayberger, and
M Sanjanwala, and
J Sklar, and
A M Krensky
August 1997,
Immunology,
H T Kim, and
E L Nelson, and
C Clayberger, and
M Sanjanwala, and
J Sklar, and
A M Krensky
January 1996,
Annual review of immunology,
H T Kim, and
E L Nelson, and
C Clayberger, and
M Sanjanwala, and
J Sklar, and
A M Krensky
July 1990,
Science (New York, N.Y.),
H T Kim, and
E L Nelson, and
C Clayberger, and
M Sanjanwala, and
J Sklar, and
A M Krensky
October 1995,
Current biology : CB,
H T Kim, and
E L Nelson, and
C Clayberger, and
M Sanjanwala, and
J Sklar, and
A M Krensky
October 1994,
Journal of immunology (Baltimore, Md. : 1950),
H T Kim, and
E L Nelson, and
C Clayberger, and
M Sanjanwala, and
J Sklar, and
A M Krensky
July 2011,
Cellular and molecular life sciences : CMLS,
H T Kim, and
E L Nelson, and
C Clayberger, and
M Sanjanwala, and
J Sklar, and
A M Krensky
January 1993,
Cancer immunology, immunotherapy : CII,
H T Kim, and
E L Nelson, and
C Clayberger, and
M Sanjanwala, and
J Sklar, and
A M Krensky
February 2004,
Internal medicine (Tokyo, Japan),
H T Kim, and
E L Nelson, and
C Clayberger, and
M Sanjanwala, and
J Sklar, and
A M Krensky
April 1993,
Current opinion in immunology,
H T Kim, and
E L Nelson, and
C Clayberger, and
M Sanjanwala, and
J Sklar, and
A M Krensky
December 2009,
Nature reviews. Clinical oncology,
