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Effects of phenyl-, benzyl-, phenethyl-, and phenylpropylphthalimides on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor necrosis factor (TNF)-alpha production by human leukemia cell line HL-60 were examined. Among the four phthalimide derivatives, only phenethylphthalimide showed potent enhancing effect on TNF-alpha production.
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