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Twenty-one male rabbits were administered with alum (aluminum potassium sulfate) for 32 weeks to study the accumulative toxic effects of aluminum in food additives on central nervous system. Results showed aluminum levels in blood and brain tissue of the animals increased significantly with intake of alum (P < 0.01). Blood zinc levels, and activities of superoxide dismutase (SOD) and monoamine oxidase B (MAO-B) correlated negatively with aluminum levels in blood and brain, and SOD activity correlated negatively to accumulative aluminum deposit and positively to lipid oxide level in brain. Pathological examinations showed lesions in gyrus centralis anterior, gyrus hippocampi and spinal cord of the animals got more severely and extensively with aluminum intake and brain aluminum content, with disarrangement of neurofilaments and neurotubule, and deformation of synaptic structures.
W Q Zhang, and
G S Xu, and
G W Huang
January 1967,
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W Q Zhang, and
G S Xu, and
G W Huang
December 1983,
Der Nervenarzt,
W Q Zhang, and
G S Xu, and
G W Huang
January 2010,
Reviews of environmental contamination and toxicology,
W Q Zhang, and
G S Xu, and
G W Huang
April 1950,
Folia psychiatrica, neurologica et neurochirurgica Neerlandica,
W Q Zhang, and
G S Xu, and
G W Huang
March 1982,
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W Q Zhang, and
G S Xu, and
G W Huang
January 1953,
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W Q Zhang, and
G S Xu, and
G W Huang
March 2007,
European journal of anaesthesiology,
W Q Zhang, and
G S Xu, and
G W Huang
July 1986,
British journal of anaesthesia,
W Q Zhang, and
G S Xu, and
G W Huang
April 2022,
International journal of molecular sciences,
W Q Zhang, and
G S Xu, and
G W Huang
April 1998,
Annals of oncology : official journal of the European Society for Medical Oncology,
