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The major histocompatibility complex class II alleles at the HLA-DPB1 locus were investigated in 32 German Caucasoid patients with primary biliary cirrhosis (PBC) and compared with those from 47 normal control patients using molecular genotyping techniques. The second exon of the HLA-DPB1 gene was amplified by polymerase chain reaction (PCR) and hybridized with 25 sequence-specific oligonucleotides (SSOs) to assign the HLA-DPB1 alleles on the basis of known sequence variations, according to the protocols of the Eleventh International Histocompatibility Workshop. A strong association of PBC was found with the allele HLA-DPB1*0301. The allele HLA DPB1*0301 was present in 50% (16 of 32) of the patients with PBC compared with 13% (6 of 47) of normal controls (P corrected < .015), whereas the other HLA-DPB1 alleles showed no significant differences in both groups. The relative risk (RR) estimate for the allele HLA-DPB1*0301 was 6.8 (95% confidence limits: 2.27 to 20.57). In summary, this study clearly demonstrates an association of PBC with the HLA-DPB1*0301 allele in German Caucasoids and may add new data to the immunogenetic background of PBC, suggesting a contribution of the HLA-DPB1 gene to the genetic susceptibility of the disease.
J G Mella, and
E Roschmann, and
K P Maier, and
B A Volk
May 1996,
Diabetes,
J G Mella, and
E Roschmann, and
K P Maier, and
B A Volk
October 2006,
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
J G Mella, and
E Roschmann, and
K P Maier, and
B A Volk
March 2004,
The Journal of allergy and clinical immunology,
J G Mella, and
E Roschmann, and
K P Maier, and
B A Volk
September 2012,
Genes and immunity,
J G Mella, and
E Roschmann, and
K P Maier, and
B A Volk
January 1991,
Research in immunology,
J G Mella, and
E Roschmann, and
K P Maier, and
B A Volk
April 2002,
Tissue antigens,
J G Mella, and
E Roschmann, and
K P Maier, and
B A Volk
January 1994,
Tissue antigens,
J G Mella, and
E Roschmann, and
K P Maier, and
B A Volk
August 1994,
Tissue antigens,
J G Mella, and
E Roschmann, and
K P Maier, and
B A Volk
June 1993,
The Quarterly journal of medicine,
J G Mella, and
E Roschmann, and
K P Maier, and
B A Volk
January 1998,
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