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The effect of prolonged diabetic state on catecholamine-induced adenosine 3',5'-monophosphate (cAMP) response in the rat liver was examined using isolated liver perfusion. Epinephrine- or isoproterenol-induced cAMP production was enhanced (10-fold of the control) in the liver from extremely emaciated (intraperitoneal adipose tissue was absent completely) diabetic rats 4 weeks after streptozotocin-injection kept without insulin, but not from adipose tissue-present diabetic rats. Glucagon-induced cAMP production was decreased in the diabetic rat liver 4 weeks after streptozotocin regardless of the presence or absence of adipose tissue. Secretin-induced cAMP production was also decreased in the adipose tissue-absent diabetic rat liver. Plasma levels of glucose or insulin were not different between adipose tissue-present and -absent diabetic rats. Liver dysfunction (elevated AST and ALT levels) was observed 1 week after streptozotocin-injection, and worsened at 4 weeks. Forskolin-induced production of cAMP, and oxymetazoline (an alpha 2-adrenergic agonist)-induced suppression of it were not different among the control, newly diabetic (1 week after streptozotocin-injection), and the adipose tissue-absent diabetic rat liver. CONCLUSIONS 1) enhanced beta-adrenergic, and decreased glucagon- or secretin-induced cAMP production seems to be caused by different mechanisms; 2) the prolonged severe diabetic state losing adipose tissue may cause a considerable change in metabolism and the characteristics of hepatocyte, and lead to enhanced beta-adrenergic cAMP production.
K Yamatani, and
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N Sato, and
K Takahashi, and
H Sasaki
October 1997,
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K Yamatani, and
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N Sato, and
K Takahashi, and
H Sasaki
December 1999,
Canadian journal of physiology and pharmacology,
K Yamatani, and
S Marubashi, and
K Wakasugi, and
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N Sato, and
K Takahashi, and
H Sasaki
April 2002,
Diabetes, nutrition & metabolism,
K Yamatani, and
S Marubashi, and
K Wakasugi, and
K Saito, and
N Sato, and
K Takahashi, and
H Sasaki
December 2022,
Life (Basel, Switzerland),
K Yamatani, and
S Marubashi, and
K Wakasugi, and
K Saito, and
N Sato, and
K Takahashi, and
H Sasaki
November 1980,
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K Yamatani, and
S Marubashi, and
K Wakasugi, and
K Saito, and
N Sato, and
K Takahashi, and
H Sasaki
September 1984,
Life sciences,
K Yamatani, and
S Marubashi, and
K Wakasugi, and
K Saito, and
N Sato, and
K Takahashi, and
H Sasaki
May 1981,
Biochemical and biophysical research communications,
K Yamatani, and
S Marubashi, and
K Wakasugi, and
K Saito, and
N Sato, and
K Takahashi, and
H Sasaki
October 2014,
Acta cirurgica brasileira,
K Yamatani, and
S Marubashi, and
K Wakasugi, and
K Saito, and
N Sato, and
K Takahashi, and
H Sasaki
May 2004,
Scandinavian journal of gastroenterology,
K Yamatani, and
S Marubashi, and
K Wakasugi, and
K Saito, and
N Sato, and
K Takahashi, and
H Sasaki
July 1994,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
