Acute basophilic leukemia is a relatively uncommon variant of acute nonlymphocytic leukemia accounting for 4-5 percent of cases of acute nonlymphocytic leukemia and less than 2 percent of all hematopoietic malignancies. It is usually characterized by a very rapid clinical course, symptoms of hyperhistaminemia, peptic ulceration, gastrointestinal cerebrovascular bleeding and resistance to therapy. This leukemia is somewhat heterogeneous in term of morphology, immunology and chromosome alterations. No specific marker chromosome has been described but trisomy 8 and monosomy 7 are the most frequent chromosomal abnormalities. The cytochemical reactions in basophilic leukemia are positive results with toluidine blue and Astra blue stains. Peroxidase stain is reported to show positive reactions. Ultrastructural analysis usually reveals immature basophil granules and provides evidence of basophilic differentiation of the blasts.