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The taxonomy of the causative agents of lower respiratory tract infections (LRTI) isolated from patients in the Moscow Region was studied and the clinico-microbiological efficacy and tolerance of ofloxacin used in their treatment were estimated. The microbiological tests of the sputum specimens from 168 patients with LRTIs most frequently detected gram positive cocci with the predominance of Streptococcus spp. (65.2 per cent) and in particular the Str. viridans group (57.7 per cent). Neisseria spp. and B. catarrhalis (18.1 per cent) were more frequent among the gram negative isolates. Gram negative bacilli were isolated in 14.3 per cent of the cases with the predominance of Pseudomonas spp. and Enterobacter spp. In 80.8 per cent of the cases the microorganisms were isolated in the form of 2-3-component associations. By the in vitro antimicrobial activity against 167 clinical isolates ofloxacin was superior to penicillins, cephalosporins, aminoglycosides, tetracyclines and cotrimoxasol. Good and satisfactory clinical effects in the treatment of 29 patients with LRTIs were observed in 17 cases (70.8 per cent). Adverse reactions were stated in 3 patients (11.5 per cent). Superinfection due to ofloxacin resistant enterococci, S. pyogenes, Neisseria spp. and yeast-like fungi developed in some patients treated with ofloxacin.
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K I Savitskaia, and
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