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In the screening tests of drugs for silicosis in our laboratory, we found that TT, a type of alkaloid isolated from Stephania tetrandra, could inhibit the development of experimental silicosis of rats and the synthesis of collagen in rat lung. Chest X-rays of silicotic patients treated with TT for 1-3 years showed obvious changes. The silicotic nodules became smaller and shadows became clearer. PVNO was proved to have anti-silicotic effect on animal and clinically. This presentation reports the effect of them on collagen mRNA. Dot blot results showed that alpha 1 (I) and alpha 1 (III) mRNA levels increased significantly at 60 and 120 days after the rats were exposed to silica dust. The mRNA levels went down at 1 and 3 months after treated by TT and PVNO. In situ hybridization observation revealed that the silver grains of Type I and Type III collagen were scattered within the fibroblasts in cellular nodules and in thickened interstitium of silicosis tissue. The amounts of mRNA silver grains decreased in the lung tissue treated by TT and PVNO. It was suggested that TT and PVNO may inhibit the gene expression of collagen during silicosis.
B C Liu, and
Y X He, and
Q Miao, and
H H Wang, and
B R You
January 1971,
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B C Liu, and
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Q Miao, and
H H Wang, and
B R You
June 1969,
Gigiena truda i professional'nye zabolevaniia,
B C Liu, and
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Q Miao, and
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October 1974,
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December 1984,
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January 1963,
Grundfragen aus der Silikoseforschung,
B C Liu, and
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Q Miao, and
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B R You
October 1963,
La Medicina del lavoro,
B C Liu, and
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May 1960,
Deutsche medizinische Wochenschrift (1946),
B C Liu, and
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March 1977,
Biulleten' eksperimental'noi biologii i meditsiny,
B C Liu, and
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August 1969,
Arzneimittel-Forschung,
B C Liu, and
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B R You
January 1977,
Gigiena truda i professional'nye zabolevaniia,
