BIOMAT Database Logo BIOMAT Database Logo

Autoradiographic characterization of 125I-neurotensin binding sites in human entorhinal cortex. 1994

S S Wolf, and T M Hyde, and T W Moody, and R C Saunders, and D R Weinberger, and J E Kleinman
Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, Washington, DC 20032.

The laminar and rostro-caudal distribution of 125I-neurotensin binding sites is described in human entorhinal cortex using quantitative autoradiography. Specific binding was most prominent over the cell clusters of layer II of the entorhinal cortex throughout its rostro-caudal extent. Dense binding was also observed in the adjacent presubiculum and cortical amygdaloid transition area, whereas minimal binding was detected in the hippocampus and dentate gyrus. 125I-Neurotensin may serve as a selective probe for neurotensin receptor alterations and layer II-specific cytoarchitectural disturbances in the entorhinal cortex in neuropsychiatric diseases associated with abnormalities of the mesial temporal lobe.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009496 Neurotensin A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D001345 Autoradiography The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed) Radioautography
D001665 Binding Sites The parts of a macromolecule that directly participate in its specific combination with another molecule. Combining Site,Binding Site,Combining Sites,Site, Binding,Site, Combining,Sites, Binding,Sites, Combining
D018728 Entorhinal Cortex Cerebral cortex region on the medial aspect of the PARAHIPPOCAMPAL GYRUS, immediately caudal to the OLFACTORY CORTEX of the uncus. The entorhinal cortex is the origin of the major neural fiber system afferent to the HIPPOCAMPAL FORMATION, the so-called PERFORANT PATHWAY. Brodmann Area 28,Brodmann Area 34,Brodmann's Area 28,Brodmann's Area 34,Entorhinal Area,Area Entorhinalis,Entorhinal Cortices,Secondary Olfactory Cortex,Area 28, Brodmann,Area 28, Brodmann's,Area 34, Brodmann,Area 34, Brodmann's,Area, Entorhinal,Brodmanns Area 28,Brodmanns Area 34,Cortex, Entorhinal,Cortex, Secondary Olfactory,Entorhinal Areas,Olfactory Cortex, Secondary,Secondary Olfactory Cortices

Related Publications

S S Wolf, and T M Hyde, and T W Moody, and R C Saunders, and D R Weinberger, and J E Kleinman
Characterization and autoradiographic distribution of neurotensin binding sites in the human brain.
December 1985, Brain research,
S S Wolf, and T M Hyde, and T W Moody, and R C Saunders, and D R Weinberger, and J E Kleinman
Characterization and autoradiographic localization of neurotensin binding sites in human sigmoid colon.
June 2001, The Journal of pharmacology and experimental therapeutics,
S S Wolf, and T M Hyde, and T W Moody, and R C Saunders, and D R Weinberger, and J E Kleinman
Ontogeny of [3H]neurotensin binding sites in the rat cerebral cortex: autoradiographic study.
February 1987, Brain research,
S S Wolf, and T M Hyde, and T W Moody, and R C Saunders, and D R Weinberger, and J E Kleinman
Autoradiographic localization of [125I]charybdotoxin binding sites in rat brain.
June 1992, Neuroscience letters,
S S Wolf, and T M Hyde, and T W Moody, and R C Saunders, and D R Weinberger, and J E Kleinman
Quantitative in vitro autoradiographic characterization of [125I]angiotensin III binding sites in rat adrenal gland.
November 1988, Regulatory peptides,
S S Wolf, and T M Hyde, and T W Moody, and R C Saunders, and D R Weinberger, and J E Kleinman
Autoradiographic visualization of the binding sites for [125I]endothelin in rat and human brain.
February 1989, Neuroscience letters,
S S Wolf, and T M Hyde, and T W Moody, and R C Saunders, and D R Weinberger, and J E Kleinman
Distribution of 125I-neurotensin binding sites in human forebrain: comparison with the localization of acetylcholinesterase.
July 1990, The Journal of comparative neurology,
S S Wolf, and T M Hyde, and T W Moody, and R C Saunders, and D R Weinberger, and J E Kleinman
Autoradiographic localization of [125I]-endothelin-1 binding sites in rat brain.
August 1989, Neuroscience research,
S S Wolf, and T M Hyde, and T W Moody, and R C Saunders, and D R Weinberger, and J E Kleinman
Autoradiographic localization of (125I-Tyr4)bombesin-binding sites in rat brain.
February 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience,
S S Wolf, and T M Hyde, and T W Moody, and R C Saunders, and D R Weinberger, and J E Kleinman
Autoradiographic localization of 125I-galanin binding sites in the blowfly brain.
December 1992, Regulatory peptides,
Copied contents to your clipboard!