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The effect of delta 8-THC on experimental autoimmune encephalomyelitis (EAE) was examined. delta 8-THC is an analogue of delta 9-THC, the psychoactive component of marijuana. It is more stable and less psychotropic than delta 9-THC and like the latter it binds to the brain cannabinoid receptor. Two strains of rats were inoculated for EAE, and delta 8-THC (40 mg/kg) was administered for up to 21 days. delta 8-THC significantly reduced the incidence and severity of neurological deficit in both rat strains. The beneficial influence of delta 8-THC only occurred on oral administration and not with parenteral injection. Serum corticosterone levels were twofold elevated in rats with EAE chronically treated with delta 8-THC. These results suggest that suppression of EAE by cannabinoids may be related to their effect on corticosterone secretion.
I Wirguin, and
R Mechoulam, and
A Breuer, and
E Schezen, and
J Weidenfeld, and
T Brenner
August 2009,
Journal of immunology (Baltimore, Md. : 1950),
I Wirguin, and
R Mechoulam, and
A Breuer, and
E Schezen, and
J Weidenfeld, and
T Brenner
August 1989,
The New England journal of medicine,
I Wirguin, and
R Mechoulam, and
A Breuer, and
E Schezen, and
J Weidenfeld, and
T Brenner
March 1990,
Acta neurologica Scandinavica,
I Wirguin, and
R Mechoulam, and
A Breuer, and
E Schezen, and
J Weidenfeld, and
T Brenner
December 1999,
Cellular immunology,
I Wirguin, and
R Mechoulam, and
A Breuer, and
E Schezen, and
J Weidenfeld, and
T Brenner
July 1992,
Journal of neuroimmunology,
I Wirguin, and
R Mechoulam, and
A Breuer, and
E Schezen, and
J Weidenfeld, and
T Brenner
February 2021,
Journal of immunology (Baltimore, Md. : 1950),
I Wirguin, and
R Mechoulam, and
A Breuer, and
E Schezen, and
J Weidenfeld, and
T Brenner
December 1998,
Experimental neurology,
I Wirguin, and
R Mechoulam, and
A Breuer, and
E Schezen, and
J Weidenfeld, and
T Brenner
May 2007,
Autoimmunity,
I Wirguin, and
R Mechoulam, and
A Breuer, and
E Schezen, and
J Weidenfeld, and
T Brenner
August 2013,
Archives of biochemistry and biophysics,
I Wirguin, and
R Mechoulam, and
A Breuer, and
E Schezen, and
J Weidenfeld, and
T Brenner
April 1993,
Journal of neuroimmunology,
