BIOMAT Database Logo BIOMAT Database Logo

Molecular characterization of beta-thalassemia in north Jordan. 1994

M F Sadiq, and T H Huisman
Department of Biological Sciences, Yarmouk University, Irbid, Jordan.

We have studied the beta-thalassemia mutations in 91 chromosomes of 43 patients with beta-thalassemia major and five with Hb S-beta-thalassemia, aged 6 months to 24 years. Many are blood transfusion-dependent and are being treated at the major hospital, the Princess Basma Hospital, in Irbid, Jordan. As many as 13 different mutations have been identified; three Mediterranean mutations [IVS-I-110 (G-->A), IVS-II-I (G-->A), and IVS-II-745 (C-->G)] were present in 54% of the chromosomes tested, while six other Mediterranean alleles were found in 24% of the chromosomes, for a total of 78% of Mediterranean origin. Sixteen chromosomes carried mutations which were observed in Arabian, Southeast Asian/Indian, and Iranian/Egyptian or Black populations; four beta-thalassemia mutations remained unidentified.

UI MeSH Term Description Entries
D007597 Jordan A country in the MIDDLE EAST, northwest of Saudi Arabia, between Israel and Iraq. The capital is Amman.
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005006 Ethnicity A group of people with a common cultural heritage that sets them apart from others in a variety of social relationships. Ethnic Groups,Nationality,Ethnic Group,Nationalities
D005787 Gene Frequency The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION. Allele Frequency,Genetic Equilibrium,Equilibrium, Genetic,Allele Frequencies,Frequencies, Allele,Frequencies, Gene,Frequency, Allele,Frequency, Gene,Gene Frequencies
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D005914 Globins A superfamily of proteins containing the globin fold which is composed of 6-8 alpha helices arranged in a characterstic HEME enclosing structure. Globin
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

M F Sadiq, and T H Huisman
Sickle cell/beta-thalassemia in North Jordan.
August 1992, Journal of tropical pediatrics,
M F Sadiq, and T H Huisman
Thyroid function in children with beta-thalassemia major in north Jordan.
April 1993, Journal of tropical pediatrics,
M F Sadiq, and T H Huisman
Beta-thalassemia in China: a systematic molecular characterization of beta-thalassemia mutations.
January 1988, Hemoglobin,
M F Sadiq, and T H Huisman
Molecular characterization of beta-thalassemia in Pakistan.
July 1998, Hemoglobin,
M F Sadiq, and T H Huisman
Molecular characterization of beta-thalassemia in Syria.
February 2000, Hemoglobin,
M F Sadiq, and T H Huisman
Molecular characterization of beta-thalassemia in Azerbaijan.
December 1992, Human genetics,
M F Sadiq, and T H Huisman
Molecular characterization of beta-thalassemia in Hungary.
October 1993, Human genetics,
M F Sadiq, and T H Huisman
Molecular characterization of beta-thalassemia in Czechoslovakia.
February 1992, Human genetics,
M F Sadiq, and T H Huisman
Molecular characterization of beta-thalassemia in Egyptians.
January 1993, Human mutation,
M F Sadiq, and T H Huisman
Molecular characterization of beta-thalassemia mutations in Egypt.
August 1990, Human genetics,
Copied contents to your clipboard!