-transparent.png){kind=logo}
The distribution of Na+,K(+)-ATPase alpha 1 subunit mRNA was identified using in situ hybridization in the developing rat cochlea. The expression of alpha 1 subunit mRNA in stria vascularis (SV) was observed in all time points studied, 1 to 30 postnatal day (pnd) rats. The adult expression level was attained between 11 to 14 pnd. Surprisingly, alpha 1 subunit mRNA in spiral ligament (SL) and spiral limbus (SLi) was expressed in a more distinct time-dependent manner. At 7 pnd, the alpha 1 subunit mRNA expression was observed initially in the tissues of the SL. At 11 pnd, alpha 1 subunit expression appeared in SLi. Between 11 and 14 pnd, an adult-like pattern of Na+,K(+)-ATPase alpha 1 subunit mRNA expression was attained in the SL and SLi. These data suggest that the expression of Na+,K(+)-ATPase alpha 1 subunit mRNA in these areas are closely related to the development of the rat EP, as its expression in the stria vascularis.
X Yao, and
W J ten Cate, and
L M Curtis, and
K E Rarey
February 1994,
The American journal of physiology,
X Yao, and
W J ten Cate, and
L M Curtis, and
K E Rarey
April 1991,
Molecular and cellular neurosciences,
X Yao, and
W J ten Cate, and
L M Curtis, and
K E Rarey
February 1999,
Biochemistry and molecular biology international,
X Yao, and
W J ten Cate, and
L M Curtis, and
K E Rarey
February 1994,
The American journal of physiology,
X Yao, and
W J ten Cate, and
L M Curtis, and
K E Rarey
October 2000,
Brain research. Developmental brain research,
X Yao, and
W J ten Cate, and
L M Curtis, and
K E Rarey
June 1988,
The Journal of biological chemistry,
X Yao, and
W J ten Cate, and
L M Curtis, and
K E Rarey
October 1996,
Hearing research,
X Yao, and
W J ten Cate, and
L M Curtis, and
K E Rarey
January 1991,
The Journal of membrane biology,
X Yao, and
W J ten Cate, and
L M Curtis, and
K E Rarey
April 2003,
Annals of the New York Academy of Sciences,
X Yao, and
W J ten Cate, and
L M Curtis, and
K E Rarey
October 1992,
The American journal of physiology,
