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Amitrole (3-amino-1,2,4-triazole) inhibits bacterial growth both in Escherichia coli and Salmonella typhimurium at a concentration of 0.5% in minimal medium. Repression of growth already occurs at a concentration of 0.1% of amitrole in this medium. In complete medium the bacteria tolerate concentrations of amitrole as high as 1.7-2.4% before growth ceases. Mutagenicity was tested by differential growth comparisons on E. coli strains W 3110 thy pol A1, defective in DNA polymerase I, and its revertant pol A+. Known mutagens (MMS, NTG, mitomycin C) were used as positive controls. Analogous negative results were also obtained in a revertant test when several trp mutant strains of Salmonella were used.
D Bamford, and
M Sorsa, and
U Gripenberg, and
I Laamanen, and
T Meretoja
February 1982,
Onkologie,
D Bamford, and
M Sorsa, and
U Gripenberg, and
I Laamanen, and
T Meretoja
June 1973,
Agents and actions,
D Bamford, and
M Sorsa, and
U Gripenberg, and
I Laamanen, and
T Meretoja
October 1976,
Mutation research,
D Bamford, and
M Sorsa, and
U Gripenberg, and
I Laamanen, and
T Meretoja
April 1976,
Applied and environmental microbiology,
D Bamford, and
M Sorsa, and
U Gripenberg, and
I Laamanen, and
T Meretoja
June 1973,
Mutation research,
D Bamford, and
M Sorsa, and
U Gripenberg, and
I Laamanen, and
T Meretoja
September 1973,
Toxicology and applied pharmacology,
D Bamford, and
M Sorsa, and
U Gripenberg, and
I Laamanen, and
T Meretoja
September 1992,
Mutation research,
D Bamford, and
M Sorsa, and
U Gripenberg, and
I Laamanen, and
T Meretoja
January 1987,
Environmental mutagenesis,
D Bamford, and
M Sorsa, and
U Gripenberg, and
I Laamanen, and
T Meretoja
January 1980,
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement,
D Bamford, and
M Sorsa, and
U Gripenberg, and
I Laamanen, and
T Meretoja
July 1985,
Mutation research,
