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Three photoproducts of merocyanine 540 have been isolated, chemically characterized and synthesized. Two of these photoproducts, merocil and merodantoin, show significant antitumor activity in vitro and in vivo while demonstrating minimal toxicity to normal cells and tissues. Treatment of lymphoma cells with these compounds resulted in a rapid decline in macromolecular synthesis, DNA fragmentation inhibitable by actinomycin D and cycloheximide, and a marked rise in intracellular calcium. In vitro analysis revealed that activity of these compounds is dependent on topoisomerase II. These results are discussed in terms of the novel class of topoisomerase II-dependent compounds for potential use in chemotherapy.
K S Gulliya, and
B Franck, and
U Schneider, and
R Sharma, and
L Arnold, and
J L Matthews
June 2008,
Cell cycle (Georgetown, Tex.),
K S Gulliya, and
B Franck, and
U Schneider, and
R Sharma, and
L Arnold, and
J L Matthews
July 2008,
Ai zheng = Aizheng = Chinese journal of cancer,
K S Gulliya, and
B Franck, and
U Schneider, and
R Sharma, and
L Arnold, and
J L Matthews
February 1991,
Cancer research,
K S Gulliya, and
B Franck, and
U Schneider, and
R Sharma, and
L Arnold, and
J L Matthews
October 2000,
Anti-cancer drugs,
K S Gulliya, and
B Franck, and
U Schneider, and
R Sharma, and
L Arnold, and
J L Matthews
November 2004,
Biochemical pharmacology,
K S Gulliya, and
B Franck, and
U Schneider, and
R Sharma, and
L Arnold, and
J L Matthews
January 2000,
Anticancer research,
K S Gulliya, and
B Franck, and
U Schneider, and
R Sharma, and
L Arnold, and
J L Matthews
January 1996,
Cancer chemotherapy and pharmacology,
K S Gulliya, and
B Franck, and
U Schneider, and
R Sharma, and
L Arnold, and
J L Matthews
March 2010,
Journal of medicinal chemistry,
K S Gulliya, and
B Franck, and
U Schneider, and
R Sharma, and
L Arnold, and
J L Matthews
August 2012,
Investigational new drugs,
K S Gulliya, and
B Franck, and
U Schneider, and
R Sharma, and
L Arnold, and
J L Matthews
January 1993,
Biochimica et biophysica acta,
