-transparent.png){kind=logo}
We review the use of 1,5-anhydroglucitol (1,5 AG) in diagnosing and monitoring patients with diabetes. This six-carbon chain monosaccharide is one of the major polyols present in humans. Its concentration in serum is normally about 12 to 40 micrograms/ml. This substance is derived mainly from food, is well absorbed in the intestine, and is distributed to all organs and tissues. It is metabolically stable, being excreted in the urine when its level exceeds the renal threshold. It is reabsorbed in the renal tubules, and is competitively inhibited by glucosuria, which leads to a reduction in its level in serum. The correlation between this reduction and the amount of glucose present in urine is so close that 1,5 AG can be used as a sensitive, day-to-day, real-time marker of glycemic control. It provides useful information on current glycemic control and is superior to both HbA1c and fructosamine in detecting near-normoglycemia.
T Yamanouchi, and
Y Akanuma
January 2003,
Diabetes technology & therapeutics,
T Yamanouchi, and
Y Akanuma
February 1995,
Nihon rinsho. Japanese journal of clinical medicine,
T Yamanouchi, and
Y Akanuma
January 2014,
Rinsho byori. The Japanese journal of clinical pathology,
T Yamanouchi, and
Y Akanuma
January 2008,
Expert review of molecular diagnostics,
T Yamanouchi, and
Y Akanuma
March 2014,
The Journal of clinical endocrinology and metabolism,
T Yamanouchi, and
Y Akanuma
October 2017,
The Journal of clinical endocrinology and metabolism,
T Yamanouchi, and
Y Akanuma
April 2019,
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association,
T Yamanouchi, and
Y Akanuma
June 1996,
Lancet (London, England),
T Yamanouchi, and
Y Akanuma
November 1994,
Clinical chemistry,
T Yamanouchi, and
Y Akanuma
June 2015,
Annals of pediatric endocrinology & metabolism,
