Biomaterial Database

[Diurnal variation in passive avoidance response and serum corticosterone in rats]. 1994

K Yamada, and T Iwasaki

Institute of Psychology, University of Tsukuba, Ibaraki.

A possible relationship between diurnal variation in performance of step-through passive avoidance response (PAR) and that in adrenocortical response was investigated. In Wistar-Imamichi strain rats, retention latency of PAR and serum corticosterone (CORT) level immediately after retention test were measured as a function of time of day. Basal CORT level was found to be low during early phase of light period, and thereafter to elevate toward dark period (Exp. 1). Eighty animals were divided into eight groups, which consisted of a combination of two diurnal times of training/testing (light phase = 14:00 and dark phase = 2:00) and four shock intensities for training (0, 0.5, 0.75, 1.0 mA) (Exp. 2). The latency of PAR was found to be longer in the light than in the dark phase, and CORT markedly increased only in the light phase in the groups with 0.75 mA. In addition, PAR was conducted at four times of day (8:00, 14:00, 20:00, 2:00) with 0.75 mA shock (Exp. 3). It was confirmed that the diurnal variation of PAR latency was associated with that the CORT elevation, with the maximum at 14:00 and the minimum at 2:00. These results indicate that diurnal variation in performance of PAR has a close relationship with that in emotional or stress response to aversive situation.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D002940	Circadian Rhythm	The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli.	Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D003345	Corticosterone	An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
D004558	Electric Stimulation	Use of electric potential or currents to elicit biological responses.	Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001362	Avoidance Learning	A response to a cue that is instrumental in avoiding a noxious experience.	Aversion Behavior,Aversion Learning,Aversive Behavior,Aversive Learning,Avoidance Behavior,Aversion Behaviors,Aversive Behaviors,Avoidance Behaviors,Behavior, Aversion,Behavior, Aversive,Behavior, Avoidance,Behaviors, Aversion,Behaviors, Aversive,Behaviors, Avoidance,Learning, Aversion,Learning, Aversive,Learning, Avoidance
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus