The most modern trends in the artery hypertension treatment recommend using the individual remedy. The modern approach to the therapy of this disease points more and more to the use of the calcium antagonists but in the scope of monotherapy. In the total mass of the cured (200), in the treated group are used Nifedplan and Verapamil, while the tested patients of the control group were treated by metilodop and hyginic--dietetics treatment. With regard to the medication the patients matched in number. The use and the impact of Nifedipine and Verapamil onto the systolic and diastolic components of blood pressure point to the statistically significant antihypertensic efficiency of both preparations. The unwanted effects are practically irrelevant which gives to the calcium antagonists priority at choice. Introducing the calcium antagonists into clinical practice is a great progress in the pharmacotherapy of many cardiovascular illnesses. They are nowadays irreplaceable at discussing the effective treatment of artery hypertension, heart ishemical illnesses, heart arrhythmias and hypertrophic obstructive myocardiopathy.