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There is little agreement about the methodology of clinical trials of antipsychotic drugs in patients with negative symptoms. A literature review revealed wide variation in experimental design, rating scales and study duration. This reflects differing views as to the definition and response to treatment of negative symptoms. Some degree of standardization would improve comparability of studies and aid the development of new compounds. Patients included in such studies should have displayed negative symptoms for at least 6 months. Depressive symptoms, positive schizophrenic symptoms and extrapyramidal signs may all influence or be confused with negative symptoms and may respond to treatment; they should be at a low level at baseline and should be measured during the study period. Studies should last at least 8 weeks. Several scales are available for measuring negative symptoms and are reviewed; a global impression score should be used additionally.
H J Möller, and
H M van Praag, and
B Aufdembrinke, and
P Bailey, and
T R Barnes, and
J Beck, and
H Bentsen, and
F X Eich, and
L Farrow, and
W W Fleischhacker
November 2013,
Schizophrenia research,
H J Möller, and
H M van Praag, and
B Aufdembrinke, and
P Bailey, and
T R Barnes, and
J Beck, and
H Bentsen, and
F X Eich, and
L Farrow, and
W W Fleischhacker
May 2014,
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
H J Möller, and
H M van Praag, and
B Aufdembrinke, and
P Bailey, and
T R Barnes, and
J Beck, and
H Bentsen, and
F X Eich, and
L Farrow, and
W W Fleischhacker
July 2021,
The British journal of psychiatry : the journal of mental science,
H J Möller, and
H M van Praag, and
B Aufdembrinke, and
P Bailey, and
T R Barnes, and
J Beck, and
H Bentsen, and
F X Eich, and
L Farrow, and
W W Fleischhacker
August 1992,
AIDS research and human retroviruses,
H J Möller, and
H M van Praag, and
B Aufdembrinke, and
P Bailey, and
T R Barnes, and
J Beck, and
H Bentsen, and
F X Eich, and
L Farrow, and
W W Fleischhacker
January 1998,
The Journal of clinical psychiatry,
H J Möller, and
H M van Praag, and
B Aufdembrinke, and
P Bailey, and
T R Barnes, and
J Beck, and
H Bentsen, and
F X Eich, and
L Farrow, and
W W Fleischhacker
January 1999,
The Journal of nutrition,
H J Möller, and
H M van Praag, and
B Aufdembrinke, and
P Bailey, and
T R Barnes, and
J Beck, and
H Bentsen, and
F X Eich, and
L Farrow, and
W W Fleischhacker
September 2007,
European psychiatry : the journal of the Association of European Psychiatrists,
H J Möller, and
H M van Praag, and
B Aufdembrinke, and
P Bailey, and
T R Barnes, and
J Beck, and
H Bentsen, and
F X Eich, and
L Farrow, and
W W Fleischhacker
April 2019,
Schizophrenia research,
H J Möller, and
H M van Praag, and
B Aufdembrinke, and
P Bailey, and
T R Barnes, and
J Beck, and
H Bentsen, and
F X Eich, and
L Farrow, and
W W Fleischhacker
November 2006,
Annals of the rheumatic diseases,
H J Möller, and
H M van Praag, and
B Aufdembrinke, and
P Bailey, and
T R Barnes, and
J Beck, and
H Bentsen, and
F X Eich, and
L Farrow, and
W W Fleischhacker
January 2005,
Comprehensive psychiatry,
