-transparent.png){kind=logo}
Strong electric shock stimulation of the rabbit front paw elicited a pressor blood pressure response regarded as noxious response. Ligands of mu opioid receptors were microinjected into the PAG to observe their effects on acupunture inhibition of the pressor response. (1) Ohmefentanyl (OMF), a mu agonist, significantly attenuated the pressor response. Mu antagonist TCTAP greatly enhanced the pressor response. (2) Electroacupuncture (EA) significantly inhibited the pressor response, the inhibition being readily reversed by TCTAP. The response after TCTAP was significantly greater than that of the control before EA. The results suggest that noxious stimulation is able to activate the mu opioid receptor of the PAG to modulate the noxious response and EA is able to enhance the activation.
M Gao, and
W Xu, and
W Chen, and
L He
January 1994,
Acupuncture & electro-therapeutics research,
M Gao, and
W Xu, and
W Chen, and
L He
July 1996,
Gastroenterology,
M Gao, and
W Xu, and
W Chen, and
L He
June 1998,
Neuroreport,
M Gao, and
W Xu, and
W Chen, and
L He
December 2007,
Cellular signalling,
M Gao, and
W Xu, and
W Chen, and
L He
October 1992,
The Journal of pharmacology and experimental therapeutics,
M Gao, and
W Xu, and
W Chen, and
L He
June 2012,
Neuroscience,
M Gao, and
W Xu, and
W Chen, and
L He
December 2010,
European journal of pharmacology,
M Gao, and
W Xu, and
W Chen, and
L He
February 1992,
Naunyn-Schmiedeberg's archives of pharmacology,
M Gao, and
W Xu, and
W Chen, and
L He
November 2008,
Journal of psychopharmacology (Oxford, England),
M Gao, and
W Xu, and
W Chen, and
L He
January 1986,
Zhen ci yan jiu = Acupuncture research,
