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The intravenous glucose tolerance and plasma insulin response to glucose infusion were analysed in a twin and family material, comprising 279 healthy subjects. The relation between the blood glucose and plasma insulin values was studied by an analysis of the principal eigenvalues. The variables obtained were corrected for sex, age and weight, and standardized with regard to mean and variance. The results showed that at least four of the variables have appreciable familial correlations, corresponding to a heritability (h2) varying between 0.38 and 0.72. These correlations could not be accounted for by common environment alone. Thus, the beta cell function in normal man, as measured by a glucose challenge test, appears to be genetically regulated.
J Lindsten, and
E Cerasi, and
R Luft, and
N Morton, and
N Ryman
October 1969,
Diabetologia,
J Lindsten, and
E Cerasi, and
R Luft, and
N Morton, and
N Ryman
June 1967,
Acta endocrinologica,
J Lindsten, and
E Cerasi, and
R Luft, and
N Morton, and
N Ryman
April 2010,
The British journal of nutrition,
J Lindsten, and
E Cerasi, and
R Luft, and
N Morton, and
N Ryman
May 1984,
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J Lindsten, and
E Cerasi, and
R Luft, and
N Morton, and
N Ryman
September 1991,
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J Lindsten, and
E Cerasi, and
R Luft, and
N Morton, and
N Ryman
July 1967,
Diabetes,
J Lindsten, and
E Cerasi, and
R Luft, and
N Morton, and
N Ryman
April 1973,
Computers in biology and medicine,
J Lindsten, and
E Cerasi, and
R Luft, and
N Morton, and
N Ryman
December 1963,
Lancet (London, England),
J Lindsten, and
E Cerasi, and
R Luft, and
N Morton, and
N Ryman
December 1980,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
J Lindsten, and
E Cerasi, and
R Luft, and
N Morton, and
N Ryman
October 1967,
The Journal of clinical investigation,
