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Of the Edinburgh cohort of approximately 130 children born to HIV-infected women, 9 are infected and alive. This article describes results from the first 18 months of a natural history study of seven of these, and two adopted children, studying the CD8 T cell-mediated cytotoxicity against HIV proteins (Gag, Tat, Pol, and Env), over time, and relating it to clinical progression and viral activity. Autologous EBV cell lines infected with vaccinia-HIV constructs were used as target cells, and bulk-cultured peripheral blood mononuclear cells as effector cells. The children ranged in age from 0 to 93 months, with six of the nine showing CTL activity to one or more HIV proteins. The specificity of the response was directed against Tat in the younger children, switching to Pol, then Gag or Env. Preliminary analysis of virological data showed no association between CTL and virus activity. The children with CTLs tended to be well clinically, but the cohort needs to be studied longer before conclusions can be made about CTL activity and HIV disease progression. Cytotoxic T lymphocyte activity has also been observed in two children diagnosed as HIV uninfected. These results show the importance of looking at CTL specificity, and may have implications in vaccine design.
K S Froebel, and
M C Aldhous, and
J Y Mok, and
J Hayley, and
M Arnott, and
J F Peutherer
November 1998,
AIDS (London, England),
K S Froebel, and
M C Aldhous, and
J Y Mok, and
J Hayley, and
M Arnott, and
J F Peutherer
January 1999,
AIDS research and human retroviruses,
K S Froebel, and
M C Aldhous, and
J Y Mok, and
J Hayley, and
M Arnott, and
J F Peutherer
November 2000,
Annals of the New York Academy of Sciences,
K S Froebel, and
M C Aldhous, and
J Y Mok, and
J Hayley, and
M Arnott, and
J F Peutherer
November 1997,
Journal of virology,
K S Froebel, and
M C Aldhous, and
J Y Mok, and
J Hayley, and
M Arnott, and
J F Peutherer
April 2006,
PLoS biology,
K S Froebel, and
M C Aldhous, and
J Y Mok, and
J Hayley, and
M Arnott, and
J F Peutherer
April 1997,
The Journal of experimental medicine,
K S Froebel, and
M C Aldhous, and
J Y Mok, and
J Hayley, and
M Arnott, and
J F Peutherer
August 2005,
AIDS research and human retroviruses,
K S Froebel, and
M C Aldhous, and
J Y Mok, and
J Hayley, and
M Arnott, and
J F Peutherer
October 1998,
Virology,
K S Froebel, and
M C Aldhous, and
J Y Mok, and
J Hayley, and
M Arnott, and
J F Peutherer
March 1999,
The Journal of infectious diseases,
K S Froebel, and
M C Aldhous, and
J Y Mok, and
J Hayley, and
M Arnott, and
J F Peutherer
March 2004,
AIDS (London, England),
