Biomaterial Database

Ameloblastoma with stromal multinucleated giant cells. 1994

B M Richard, and M Thyveetil, and H Sharif, and N A Athanasou

International Nepal Fellowship, Pokhara.

We report a case of ameloblastoma which uniquely showed heavy osteoclast-like giant cell accumulation and woven bone formation in the surrounding fibrous stroma. Immunohistochemistry showed that the giant cells were non-epithelial in origin and suggested that stromal factors (i.e., the presence or absence of mineralized bone) determines whether these cells express an osteoclastic antigenic phenotype.

UI	MeSH Term	Description	Entries
D008441	Maxillary Neoplasms	Cancer or tumors of the MAXILLA or upper jaw.	Maxillary Neoplasm,Neoplasm, Maxillary,Neoplasms, Maxillary
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000564	Ameloblastoma	An immature epithelial tumor of the JAW originating from the epithelial rests of Malassez or from other epithelial remnants of the ENAMEL from the developmental period. It is a slowly growing tumor, usually benign, but displays a marked propensity for invasive growth.	Ameloblastomas
D015726	Giant Cells	Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.	Giant Cells, Multinucleated,Multinucleated Giant Cells,Polykaryocytes,Syncytium,Syncytia,Cell, Giant,Cell, Multinucleated Giant,Cells, Giant,Cells, Multinucleated Giant,Giant Cell,Giant Cell, Multinucleated,Multinucleated Giant Cell,Polykaryocyte