Biomaterial Database

Acute effects of marijuana smoking on aggressive, escape and point-maintained responding of male drug users. 1993

D R Cherek, and J D Roache, and M Egli, and C Davis, and R Spiga, and K Cowan

Department of Psychiatry and Behavioral Sciences, University of Texas, Health Science Center at Houston 77030-3497.

Aggressive, escape and point-maintained operant responding of male marijuana smokers were measured during six 25-min sessions conducted over an 8-h experimental day. Aggressive responding ostensibly subtracted points exchangeable for money from another subject. Escape responding protected the subject's counter from point subtractions initiated by the other subject for some period of time. Aggressive and escape responding were engendered by subtracting points from the subjects and maintained by initiation of intervals free of point subtractions. Point subtractions presented to the subjects were attributed to other persons. Subjects earned points exchangeable for money on a third response option. Subjects participated in one session prior to smoking and five sessions after smoking. Subjects smoked placebo or three different potencies of active marijuana cigarettes. Marijuana smoking effects on escape responding were not significant and depended upon the frequency of provocation. Point-maintained responding was decreased after marijuana smoking. Aggressive responding was increased for the first hour after smoking and returned to placebo levels later in the day. These effects of marijuana smoking on aggressive responding are discussed in terms of subject characteristics, particularly drug use history.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008385	Marijuana Smoking	Inhaling and exhaling SMOKE from CANNABIS.	Cannabis Smoking,Hashish Smoking,Marihuana Smoking,Smoking Blunts,Smoking, Blunts,Blunt, Smoking,Blunts Smoking,Blunts Smokings,Blunts, Smoking,Smoking Blunt,Smoking, Cannabis,Smoking, Hashish,Smoking, Marihuana,Smoking, Marijuana,Smokings, Blunts
D002186	Cannabinoids	Compounds having the cannabinoid structure. They were originally extracted from Cannabis sativa L. The most pharmacologically active constituents are TETRAHYDROCANNABINOL; CANNABINOL; and CANNABIDIOL.	Cannabinoid
D003216	Conditioning, Operant	Learning situations in which the sequence responses of the subject are instrumental in producing reinforcement. When the correct response occurs, which involves the selection from among a repertoire of responses, the subject is immediately reinforced.	Instrumental Learning,Learning, Instrumental,Operant Conditioning,Conditionings, Operant,Instrumental Learnings,Learnings, Instrumental,Operant Conditionings
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004924	Escape Reaction	Innate response elicited by sensory stimuli associated with a threatening situation, or actual confrontation with an enemy.	Flight Reaction,Escape Reactions,Flight Reactions,Reaction, Escape,Reaction, Flight,Reactions, Escape,Reactions, Flight
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000339	Affect	The feeling-tone accompaniment of an idea or mental representation. It is the most direct psychic derivative of instinct and the psychic representative of the various bodily changes by means of which instincts manifest themselves.	Mood,Affects,Moods