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Experiments have shown that PQS (0.03-3 mg/ml) can inhibit the contractility of papillary muscle of guinea pigs, and on depolarized sample of papillary muscle with high potassium, PQS (0.03-0.3 mg/ml) can increase this contractility. Monomer saponin-Re (10 mg/kg),-Rb3 (30 mg/kg) can inhibit the hemodynamic indication of rats, but pseudogisenoside-F11 (10 mg/kg) acts the other way round. These results prove that PQS contains two components of opposite actions.
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