-transparent.png){kind=logo}
Plasma levels of urokinase-type plasminogen activator (u-PA) were measured with an enzyme-linked immunosorbent assay in patients with leukemias. As compared with healthy subjects (0.73 +/- SD 0.17 ng/ml), plasma u-PA antigen level was markedly elevated in patients with acute promyelocytic leukemia (APL) (1.76 +/- 0.89 ng/ml) at disease onset. Mean u-PA concentrations in patients with other acute nonlymphoblastic leukemia (0.57 +/- 0.51 ng/ml), acute lymphoblastic leukemia (0.77 +/- 0.82 ng/ml) and chronic myelocytic leukemia in blastic crisis (1.30 +/- 1.35 ng/ml) were not significantly elevated, but some of them showed an elevation of plasma u-PA. Plasma u-PA values were correlated with some of the fibrinolytic parameters such as FDP and D-dimer. Plasma u-PA antigen was decreased after the administration of antileukemic drugs in patients with APL. These results suggest that the coagulopathy in patients with various leukemias may in part be associated with u-PA release from the leukemic cells, especially in patients with APL.
K Wada, and
H Takahashi, and
M Hanano, and
W Tatewaki, and
H Niwano, and
Y Seki, and
A Shibata
January 2009,
Thrombosis research,
K Wada, and
H Takahashi, and
M Hanano, and
W Tatewaki, and
H Niwano, and
Y Seki, and
A Shibata
November 2007,
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery,
K Wada, and
H Takahashi, and
M Hanano, and
W Tatewaki, and
H Niwano, and
Y Seki, and
A Shibata
August 2011,
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue,
K Wada, and
H Takahashi, and
M Hanano, and
W Tatewaki, and
H Niwano, and
Y Seki, and
A Shibata
May 2000,
British journal of haematology,
K Wada, and
H Takahashi, and
M Hanano, and
W Tatewaki, and
H Niwano, and
Y Seki, and
A Shibata
December 2012,
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
K Wada, and
H Takahashi, and
M Hanano, and
W Tatewaki, and
H Niwano, and
Y Seki, and
A Shibata
January 2007,
The international journal of biochemistry & cell biology,
K Wada, and
H Takahashi, and
M Hanano, and
W Tatewaki, and
H Niwano, and
Y Seki, and
A Shibata
May 1998,
Breast cancer research and treatment,
K Wada, and
H Takahashi, and
M Hanano, and
W Tatewaki, and
H Niwano, and
Y Seki, and
A Shibata
March 2008,
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology,
K Wada, and
H Takahashi, and
M Hanano, and
W Tatewaki, and
H Niwano, and
Y Seki, and
A Shibata
September 2006,
Zhonghua nan ke xue = National journal of andrology,
K Wada, and
H Takahashi, and
M Hanano, and
W Tatewaki, and
H Niwano, and
Y Seki, and
A Shibata
August 2005,
The Journal of urology,
