-transparent.png){kind=logo}
In this study, the mechanisms for suppression of immunoglobulin production by lymphocytes induced by diphenylhydantoin (DPH) were investigated using peripheral blood mononuclear cells from one patient 3 months after discontinuation of DPH, when IgA deficiency was improved. Immunoglobulin production in PBMCs was dose-dependently suppressed by DPH and the suppressive effect of DPH on IgA production tended to be greater than the effect on IgM or IgG production. Moreover, cell separation experiments indicated that DPH suppresses immunoglobulin production by PBMCs through a suppression of B cell, but not T cell, function. The finding that the suppressive effect of DPH on IgA production tended to be greater than the effect on IgM or IgG production might be related to the fact that the alpha-chain gene is located in the 3' end of the gene coding the constant regions of human heavy chains.
N Kondo, and
A Takao, and
S Tomatsu, and
N Shimozawa, and
Y Suzuki, and
T Ogawa, and
H Iwata, and
T Orii
May 1991,
Journal of clinical immunology,
N Kondo, and
A Takao, and
S Tomatsu, and
N Shimozawa, and
Y Suzuki, and
T Ogawa, and
H Iwata, and
T Orii
January 1989,
Archives of dermatological research,
N Kondo, and
A Takao, and
S Tomatsu, and
N Shimozawa, and
Y Suzuki, and
T Ogawa, and
H Iwata, and
T Orii
September 1976,
The Journal of laboratory and clinical medicine,
N Kondo, and
A Takao, and
S Tomatsu, and
N Shimozawa, and
Y Suzuki, and
T Ogawa, and
H Iwata, and
T Orii
November 1993,
In vitro cellular & developmental biology. Animal,
N Kondo, and
A Takao, and
S Tomatsu, and
N Shimozawa, and
Y Suzuki, and
T Ogawa, and
H Iwata, and
T Orii
June 1989,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
N Kondo, and
A Takao, and
S Tomatsu, and
N Shimozawa, and
Y Suzuki, and
T Ogawa, and
H Iwata, and
T Orii
December 1970,
The Journal of pediatrics,
N Kondo, and
A Takao, and
S Tomatsu, and
N Shimozawa, and
Y Suzuki, and
T Ogawa, and
H Iwata, and
T Orii
April 1970,
The Journal of pediatrics,
N Kondo, and
A Takao, and
S Tomatsu, and
N Shimozawa, and
Y Suzuki, and
T Ogawa, and
H Iwata, and
T Orii
January 1970,
Acta morphologica Academiae Scientiarum Hungaricae,
N Kondo, and
A Takao, and
S Tomatsu, and
N Shimozawa, and
Y Suzuki, and
T Ogawa, and
H Iwata, and
T Orii
April 1989,
Casopis lekaru ceskych,
N Kondo, and
A Takao, and
S Tomatsu, and
N Shimozawa, and
Y Suzuki, and
T Ogawa, and
H Iwata, and
T Orii
October 1972,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
