[Isolation of Bordetella pertussis from patients with pertussis-like symptoms and estimation of vaccine efficacy]. 1994

M Matsumoto, and T Sakakibara, and S Arakawa, and M Saito
Aichi Prefectural Institute of Public Health.

In order to investigate the distribution of Bordetella pertussis in Nagoya City and estimate efficacy of the vaccine, we tried to isolate B. pertussis from patients with Pertussis-like symptoms who went to the department of pediatric general hospitals in Nagoya City from 1989 to 1992. B. pertussis were isolated from 43 patients among 164 patients with Pertussis-like symptoms. All of these isolates were classified into 1, 3, 6 serotype. It was impossible to isolate any B. pertussis in 1992 because of yearly variations. B. pertussis was only isolated from patients who were not vaccinated. Among the 28 siblings of the patients, 18 were vaccinated and 2 fell ill, but the latter had only mild symptoms. Three did not fall ill although they had an incomplete vaccination. According to these results we suggest that this component vaccine is effective.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D010567 Pertussis Vaccine A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed) Vaccine, Pertussis
D001886 Bordetella pertussis A species of gram-negative, aerobic bacteria that is the causative agent of WHOOPING COUGH. Its cells are minute coccobacilli that are surrounded by a slime sheath. Bacterium tussis-convulsivae,Haemophilus pertussis,Hemophilus pertussis
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014611 Vaccination Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis. Immunization, Active,Active Immunization,Active Immunizations,Immunizations, Active,Vaccinations
D014917 Whooping Cough A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath. Pertussis,Bordetella pertussis Infection, Respiratory,Cough, Whooping,Pertusses

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