[Effects of lowly dosed gestagen pill Exlutona on carbohydrate and fat metabolism (author's transl)]. 1976

E G Loch, and E Kaiser, and Christl

Due to the precautions stopping of megestrol containing oral contraceptives the prescription of oral contraceptives has again become problematic. Oral contraceptives taken over a longer period can cause occasionally side effects which then cause a stopping of these medicaments. In order to get a survey of possible effects on the carbohydrate and fat metabolism 60 patients at the age of 16-26 years who had not been pregnant were observed over a longer period and their laboratory parameters (serum insulin, triglycerides, cholesterol, total lipids) were controlled. Significant changes were only found in the total lipids in the sense of a reduction of the total lipid level. A marked reduction was found with the triglycerides. Basing on these results and taking into consideration the occasionally occurring menstrual irregularity this lowly dosed gestagen pill Exlutona can be recommended not only to young girls but also to patients who often suffer from a relative contraindication because of adiposity, hypertension and subclinical diabetes.

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D008055 Lipids A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed) Lipid
D008234 Lynestrenol A synthetic progestational hormone used often in mixtures with estrogens as an oral contraceptive (CONTRACEPTIVES, ORAL). 19-Norpregn-4-en-20-yn-17-ol, (17alpha)-,Ethinylestrenol,Exluton,Linesterol,Linestrenol,Lynestrenol, (9 beta, 10 alpha,17 alpha)-Isomer,Lynoestrenol
D002784 Cholesterol The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Epicholesterol
D002986 Clinical Trials as Topic Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries. Clinical Trial as Topic
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D014280 Triglycerides An ester formed from GLYCEROL and three fatty acid groups. Triacylglycerol,Triacylglycerols,Triglyceride

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