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Retinal pigment epithelium (RPE) cells migrating through the damaged retina play an important role in the pathogenesis of proliferative vitreoretinopathy (PVR). We found that alpha-tocopherol (vitamin E) inhibits proliferation of human RPE in culture without exerting cytotoxic effects. Maximal inhibition was achieved with 100 microM alpha-tocopherol. Our result could explain the observation that vitamin E supplements have an adverse effect on light-damaged retina and on the course of retinitis pigmentosa. Since it has been shown that supplemental oral administrations of vitamin E can raise the RPE concentration of alpha-tocopherol well above 100 microM and supplementation is not associated with any clinical relevant adverse effect, we believe that vitamin E could be beneficial in the treatment of PVR.
D Mojon, and
D Boscoboinik, and
A Haas, and
M Bohnke, and
A Azzi
July 1996,
German journal of ophthalmology,
D Mojon, and
D Boscoboinik, and
A Haas, and
M Bohnke, and
A Azzi
January 2000,
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft,
D Mojon, and
D Boscoboinik, and
A Haas, and
M Bohnke, and
A Azzi
March 1996,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
D Mojon, and
D Boscoboinik, and
A Haas, and
M Bohnke, and
A Azzi
June 1992,
Current eye research,
D Mojon, and
D Boscoboinik, and
A Haas, and
M Bohnke, and
A Azzi
October 2014,
International journal of molecular medicine,
D Mojon, and
D Boscoboinik, and
A Haas, and
M Bohnke, and
A Azzi
November 1989,
Archives of ophthalmology (Chicago, Ill. : 1960),
D Mojon, and
D Boscoboinik, and
A Haas, and
M Bohnke, and
A Azzi
May 2018,
Molecular medicine reports,
D Mojon, and
D Boscoboinik, and
A Haas, and
M Bohnke, and
A Azzi
June 1994,
Experimental cell research,
D Mojon, and
D Boscoboinik, and
A Haas, and
M Bohnke, and
A Azzi
December 2004,
Yan ke xue bao = Eye science,
D Mojon, and
D Boscoboinik, and
A Haas, and
M Bohnke, and
A Azzi
July 1975,
American journal of ophthalmology,
