The indications, method, results and complications of various thrombolytic medical treatment options in acute myocardial infarction is discussed. The thrombolytic treatment decreases the in-hospital and late mortality of patients and prevents the deterioration of left ventricular function. The earlier the treatment is initiated, the better result may be expected. The indication of thrombolysis may be expanded for patient with left bundle branch block, higher age groups, and also for late admissions after the onset of chest pain.