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The alteration of indices of 125-I insulin binding to receptors in the reactions with human erythrocytes, with their membranes and with solubilized insulin receptors in the presence of type 2 diabetics' blood serum was demonstrated (decrease of the number of insulin binding sites and increase of the dissociation constant). Treatment of patients' erythrocytes with acetate buffer solution (0.1 M, pH 5, 150 mM sodium chloride) restored the level of specific binding of insulin to normal values. It is supposed that in insulin-independent diabetes mellitus patients' serum there are specific blocking factors which interact immediately with insulin receptors thus preventing them from hormone binding or reducing their affinity.
V V Korpachev, and
N M Gurina, and
Zh V Ivanova
December 1988,
Endocrinologia experimentalis,
V V Korpachev, and
N M Gurina, and
Zh V Ivanova
January 1982,
Journees annuelles de diabetologie de l'Hotel-Dieu,
V V Korpachev, and
N M Gurina, and
Zh V Ivanova
October 1983,
Indian journal of biochemistry & biophysics,
V V Korpachev, and
N M Gurina, and
Zh V Ivanova
January 1983,
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association,
V V Korpachev, and
N M Gurina, and
Zh V Ivanova
December 1983,
Annales de pediatrie,
V V Korpachev, and
N M Gurina, and
Zh V Ivanova
September 1985,
American journal of veterinary research,
V V Korpachev, and
N M Gurina, and
Zh V Ivanova
March 1981,
Clinical endocrinology,
V V Korpachev, and
N M Gurina, and
Zh V Ivanova
March 1999,
Polskie Archiwum Medycyny Wewnetrznej,
V V Korpachev, and
N M Gurina, and
Zh V Ivanova
August 1971,
Proceedings of the National Academy of Sciences of the United States of America,
V V Korpachev, and
N M Gurina, and
Zh V Ivanova
September 1984,
Biochemical and biophysical research communications,
