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The toxicity, immunogenic properties and protective activity of the live culture of E. coli M17 and antigenic preparations obtained from cell suspensions of this strain have been studied under experimental conditions. As revealed in experiments on mice, E. coli M17 live culture has low virulence, moderate toxicity and provides the protection of immunized mice from challenge with homologous and highly virulent E. coli strains. E. coli M17 live culture, when introduced orally or intravenously into rabbits, ensures the synthesis of 02 and H6 antibodies. Blood sera taken from immunized rabbits yield better results than initial sera in experiments on the passive protection of mice. The results of our experiments show the expediency of the clinical trials of Colibacterin as a perspective Escherichia live oral vaccine.
L A Levina, and
E V Zaĭtseva, and
R M Temper, and
T A Chulok
October 1985,
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology,
L A Levina, and
E V Zaĭtseva, and
R M Temper, and
T A Chulok
March 1964,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
L A Levina, and
E V Zaĭtseva, and
R M Temper, and
T A Chulok
May 1984,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
L A Levina, and
E V Zaĭtseva, and
R M Temper, and
T A Chulok
October 2001,
Bulletin of experimental biology and medicine,
L A Levina, and
E V Zaĭtseva, and
R M Temper, and
T A Chulok
July 1993,
Journal of industrial microbiology,
L A Levina, and
E V Zaĭtseva, and
R M Temper, and
T A Chulok
January 1992,
Journal of industrial microbiology,
L A Levina, and
E V Zaĭtseva, and
R M Temper, and
T A Chulok
January 1975,
In vitro,
L A Levina, and
E V Zaĭtseva, and
R M Temper, and
T A Chulok
April 1971,
Ceskoslovenska farmacie,
L A Levina, and
E V Zaĭtseva, and
R M Temper, and
T A Chulok
January 2003,
Methods in molecular biology (Clifton, N.J.),
L A Levina, and
E V Zaĭtseva, and
R M Temper, and
T A Chulok
January 1977,
Genetika,
